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学科主题: 药学
题名:
Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis
作者: Fan, Chao1; Li, Xinru1; Zhou, Yanxia1; Zhao, Yong1; Ma, Shujin1; Li, Wenjing1; Liu, Yan1; Li, Guiling2,3
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2013
DOI: 10.1155/2013/161943
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: IN-VITRO EVALUATION ; DRUG-DELIVERY ; SKIN DELIVERY ; FUTURE-PROSPECTS ; LIPOSOMES ; CARRIERS ; VIVO ; GLYCYRRHIZINATE ; NANOPARTICLES ; FANGCHINOLINE
英文摘要:

The purpose of this work was to explore the feasibility of ethosomes for improving the antiarthritic efficacy of tetrandrine by topical application. It was found that tetrandrine was a weak base (pK(a) = 7.06) with pH-dependent partition coefficient. The spherical-shaped ethosomes were prepared by pH gradient loading method. Ex vivo permeation and deposition behavior demonstrated that the drug flux across rat skin and deposition of the drug in rat skin for ethosomes was 2.1- and 1.7-fold higher than that of liposomes, respectively. Confocal laser scanning microscopy confirmed that ethosomes could enhance the topical delivery of the drug in terms of depth and quantity compared with liposomes. The ethosomes were shown to generate substantial enhancement of therapeutic efficacy of tetrandrine on Freund′s complete adjuvant-induced arthritis with regard to liposomes. These results indicated that ethosomes would be a promising carrier for topical delivery of tetrandrine into and across the skin.

语种: 英语
所属项目编号: 81172990 ; 2009CB930300 ; BMU20110263
项目资助者: National Natural Science Foundation of China ; National Key Science Research Program of China (973 Program) ; Innovation Team of Ministry of Education ; Open Project Program of State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research
WOS记录号: WOS:000323979600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55380
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
2.Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China
3.Chinese Acad Med Sci, Beijing 100050, Peoples R China

Recommended Citation:
Fan, Chao,Li, Xinru,Zhou, Yanxia,et al. Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis[J]. BIOMED RESEARCH INTERNATIONAL,2013.
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