IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis
Fan, Chao1; Li, Xinru1; Zhou, Yanxia1; Zhao, Yong1; Ma, Shujin1; Li, Wenjing1; Liu, Yan1; Li, Guiling2,3
刊名BIOMED RESEARCH INTERNATIONAL
2013
DOI10.1155/2013/161943
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]IN-VITRO EVALUATION ; DRUG-DELIVERY ; SKIN DELIVERY ; FUTURE-PROSPECTS ; LIPOSOMES ; CARRIERS ; VIVO ; GLYCYRRHIZINATE ; NANOPARTICLES ; FANGCHINOLINE
英文摘要

The purpose of this work was to explore the feasibility of ethosomes for improving the antiarthritic efficacy of tetrandrine by topical application. It was found that tetrandrine was a weak base (pK(a) = 7.06) with pH-dependent partition coefficient. The spherical-shaped ethosomes were prepared by pH gradient loading method. Ex vivo permeation and deposition behavior demonstrated that the drug flux across rat skin and deposition of the drug in rat skin for ethosomes was 2.1- and 1.7-fold higher than that of liposomes, respectively. Confocal laser scanning microscopy confirmed that ethosomes could enhance the topical delivery of the drug in terms of depth and quantity compared with liposomes. The ethosomes were shown to generate substantial enhancement of therapeutic efficacy of tetrandrine on Freund′s complete adjuvant-induced arthritis with regard to liposomes. These results indicated that ethosomes would be a promising carrier for topical delivery of tetrandrine into and across the skin.

语种英语
WOS记录号WOS:000323979600001
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55380
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
2.Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China
3.Chinese Acad Med Sci, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Fan, Chao,Li, Xinru,Zhou, Yanxia,et al. Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis[J]. BIOMED RESEARCH INTERNATIONAL,2013.
APA Fan, Chao.,Li, Xinru.,Zhou, Yanxia.,Zhao, Yong.,Ma, Shujin.,...&Li, Guiling.(2013).Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis.BIOMED RESEARCH INTERNATIONAL.
MLA Fan, Chao,et al."Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis".BIOMED RESEARCH INTERNATIONAL (2013).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fan, Chao]的文章
[Li, Xinru]的文章
[Zhou, Yanxia]的文章
百度学术
百度学术中相似的文章
[Fan, Chao]的文章
[Li, Xinru]的文章
[Zhou, Yanxia]的文章
必应学术
必应学术中相似的文章
[Fan, Chao]的文章
[Li, Xinru]的文章
[Zhou, Yanxia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。