IR@PKUHSC  > 北京大学深圳医院  > 肿瘤内科
学科主题临床医学
Clinicopathological and Prognostic Significance of CD24 Overexpression in Patients with Gastric Cancer: A Meta-Analysis
Wu, Jing-Xun1; Zhao, Yuan-Yuan2; Wu, Xuan3; An, Han-Xiang1
刊名PLOS ONE
2014-12-12
DOI10.1371/journal.pone.0114746
9期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HEAT-STABLE ANTIGEN ; P-SELECTIN ; SIGNAL-TRANSDUCTION ; CELLS ; EXPRESSION ; CARCINOMA ; ADENOCARCINOMA ; PROGRESSION ; METASTASIS ; SURVIVAL
英文摘要

Objective: The prognostic significance of CD24 expression for survival in patients with gastric cancer remains controversial. We conducted a meta-analysis to investigate the impact of CD24 expression on clinicopathological features and survival outcomes in gastric cancer.

Methods: A comprehensive literature search of the electronic databases PubMed, Embase, Web of Science and China National Knowledge Infrastructure (CNKI; up to April 8, 2014) was performed for relevant studies using multiple search strategies. Correlations between CD24 expression and clinicopathological features and overall survival (OS) were analyzed.

Results: A total of 1,041 patients with gastric cancer from 9 studies were included. The pooled odds ratios (ORs) indicated CD24 expression was associated with tumor depth (OR=0.45, 95% confidence interval [CI] 50.32-0.63; P<0.00001), status of lymph nodes (OR=0.40, 95% CI=0.25-0.64; P=0.0001) and tumor node metastasis (TNM) stage (OR=0.56, 95% CI=0.41-0.77; P=0.0003). The pooled hazard ratio (HR) for OS showed overexpression of CD24 reduced OS in gastric cancer (HR=1.99, 95% CI=1.29-3.07, P=0.002). Whereas, combined ORs showed that CD24 expression had no correlation with tumor differentiation or Lauren classifications.

Conclusion: CD24 overexpression in patients with gastric cancer indicated worse survival outcomes and was associated with common clinicopathological poor prognostic factors.

语种英语
WOS记录号WOS:000346375400048
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55381
Collection北京大学深圳医院_肿瘤内科
作者单位1.Xiamen Univ, Affiliated Hosp 1, Dept Med Oncol, Xiamen, Fujian, Peoples R China
2.Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Med Oncol, Shenzhen, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Wu, Jing-Xun,Zhao, Yuan-Yuan,Wu, Xuan,et al. Clinicopathological and Prognostic Significance of CD24 Overexpression in Patients with Gastric Cancer: A Meta-Analysis[J]. PLOS ONE,2014,9(12).
APA Wu, Jing-Xun,Zhao, Yuan-Yuan,Wu, Xuan,&An, Han-Xiang.(2014).Clinicopathological and Prognostic Significance of CD24 Overexpression in Patients with Gastric Cancer: A Meta-Analysis.PLOS ONE,9(12).
MLA Wu, Jing-Xun,et al."Clinicopathological and Prognostic Significance of CD24 Overexpression in Patients with Gastric Cancer: A Meta-Analysis".PLOS ONE 9.12(2014).
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