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学科主题: 临床医学
题名:
F10 gene hypomethylation, a putative biomarker for glioma prognosis
作者: Liu, Xiaoping1,2,3,4; Tang, Hailin1,2,3,4,5; Wang, Zeyou1,2,3,4; Huang, Chen6; Zhang, Zuping1,2,3,4,7; She, Xiaoling1,2,3,4,8; Wu, Minghua1,2,3,4; Li, Guiyuan1,2,3,4
关键词: Glioma ; F10 ; Hypomethylation ; Prognosis
刊名: JOURNAL OF NEURO-ONCOLOGY
发表日期: 2012-05-01
DOI: 10.1007/s11060-011-0775-2
卷: 107, 期:3, 页:479-485
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Clinical Neurology
研究领域[WOS]: Oncology ; Neurosciences & Neurology
关键词[WOS]: CANCER ; METHYLATION ; EPIGENETICS ; CELLS
英文摘要:

Tumors are usually characterized by an imbalance in cytosine methylation, including hypomethylation of CpG islands. In this study, bisulfite sequencing PCR was used to assess the promoter methylation status of coagulation factor X (F10) gene in tumors of 96 glioma patients and in glioma cells U251, SF767, and SF126, and the effect of promoter hypomethylation on protein expression was evaluated immunohistochemically. The study showed that the demethylation ratio of F10 in SF126, SF767, and U251 cells was 38.6, 26.4, and 24.3% respectively. Hypomethylation of F10 was detected in 82.3% of glioma specimens and in no normal brain tissues, with significant correlation with its protein expression. However there was no remarkable relationship between F10 hypomethylation and sex, age, and advanced tumor grade. The correlation between F10 hypomethylation, protein expression, and overall survival (OS) was statistically significant. Hypomethylation of F10 promoter in gliomas accounted for F10 encoding protein FX overexpression and aggressive biological behavior in a subset of patients. Furthermore, in the F10 hypomethylation group, OS was shorter for patients with F10 overexpression than for those without. Detection of these epigenetic changes in tumors may provide important information regarding prognosis.

语种: 英语
所属项目编号: 111-2-12 ; 81171932 ; 30901539 ; 30901718 ; NCET-08-0562 ; 11JJ1013
项目资助者: 111 project ; National Science Foundation of China ; Program for New Century Excellent Talents in University ; Hunan Province Natural Sciences Foundations of China
WOS记录号: WOS:000303469400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55382
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Cent S Univ, Canc Res Inst, Changsha, Hunan, Peoples R China
2.Minist Hlth, Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China
3.Univ S China, Canc Res Inst, Hengyang 421001, Peoples R China
4.Cent S Univ, Dis Genome Res Ctr, Changsha, Hunan, Peoples R China
5.Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha, Hunan, Peoples R China
6.Peking Univ, Hosp 3, Med Res Ctr, Beijing 100871, Peoples R China
7.Cent S Univ, Xiangya Med Sch, Dept Parasitol, Changsha, Hunan, Peoples R China
8.Cent S Univ, Xiangya Hosp 2, Dept Pathol, Changsha, Hunan, Peoples R China

Recommended Citation:
Liu, Xiaoping,Tang, Hailin,Wang, Zeyou,et al. F10 gene hypomethylation, a putative biomarker for glioma prognosis[J]. JOURNAL OF NEURO-ONCOLOGY,2012,107(3):479-485.
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