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Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats
Jiang, Hong1; Fang, Dong1; Kong, Ling-Yu1; Jin, Zi-Run1; Cai, Jie1; Kang, Xue-Jing1; Wan, You2,3,4; Xing, Guo-Gang1,2,3,4
刊名MOLECULAR BRAIN
2014-10-04
DOI10.1186/s13041-014-0072-z
7期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MEMBRANE-POTENTIAL OSCILLATIONS ; SPIKE FREQUENCY ADAPTATION ; CEREBELLAR GRANULE CELLS ; INFERIOR OLIVE NEURONS ; CA1 PYRAMIDAL NEURONS ; OPEN-FIELD TEST ; SUBTHRESHOLD OSCILLATIONS ; CALCIUM-CHANNELS ; THALAMOCORTICAL NEURONS ; PERIPHERAL NEUROPATHY
英文摘要

Background: Despite high prevalence of anxiety accompanying with chronic pain, the mechanisms underlying pain-related anxiety are largely unknown. With its well-documented role in pain and emotion processing, the amygdala may act as a key player in pathogenesis of neuropathic pain-related anxiety. Pain-related plasticity and sensitization of CeA (central nucleus of the amygdala) neurons have been shown in several models of chronic pain. In addition, firing pattern of neurons with spike output can powerfully affect functional output of the brain nucleus, and GABAergic neurons are crucial in the modulation of neuronal excitability. In this study, we first investigated whether pain-related plasticity (e.g. alteration of neuronal firing patterns) and sensitization of CeA neurons contribute to nerve injury-evoked anxiety in neuropathic rats. Furthermore, we explored whether GABAergic disinhibition is responsible for regulating firing patterns and intrinsic excitabilities of CeA neurons as well as for pain-related anxiety in neuropathic rats.

Results: We discovered that spinal nerve ligation (SNL) produced neuropathic pain-related anxiety-like behaviors in rats, which could be specifically inhibited by intra-CeA administration of anti-anxiety drug diazepam. Moreover, we found potentiated plasticity and sensitization of CeA neurons in SNL-induced anxiety rats, of which including: 1) increased burst firing pattern and early-adapting firing pattern; 2) increased spike frequency and intrinsic excitability; 3) increased amplitude of both after-depolarized-potential (ADP) and sub-threshold membrane potential oscillation. In addition, we observed a remarkable reduction of GABAergic inhibition in CeA neurons in SNL-induced anxiety rats, which was proved to be important for altered firing patterns and hyperexcitability of CeA neurons, thereby greatly contributing to the development of neuropathic pain-related anxiety. Accordantly, activation of GABAergic inhibition by intra-CeA administration of muscimol, a selective GABA(A) receptors agonist, could inhibit SNL-induced anxiety-like behaviors in neuropathic rats. By contrast, suppression of GABAergic inhibition by intra-CeA administration of bicuculline, a selective GABA(A) receptors antagonist, produced anxiety-like behavior in normal rats. (Continued on next page)

语种英语
WOS记录号WOS:000344898400001
项目编号81371237 ; 31171063 ; 81072951 ; 7112079 ; 201302013-01 ; 2013CB531905
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; special foundation for public welfare profession scientific research program from Ministry of Health of the Peoples Republic of China ; 973 Program of the Ministry of Science and Technology of China
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55384
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
3.Minist Hlth, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China
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GB/T 7714
Jiang, Hong,Fang, Dong,Kong, Ling-Yu,et al. Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats[J]. MOLECULAR BRAIN,2014,7(1).
APA Jiang, Hong.,Fang, Dong.,Kong, Ling-Yu.,Jin, Zi-Run.,Cai, Jie.,...&Xing, Guo-Gang.(2014).Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats.MOLECULAR BRAIN,7(1).
MLA Jiang, Hong,et al."Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats".MOLECULAR BRAIN 7.1(2014).
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