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学科主题: 药学
题名:
A concise synthesis of 4,6-dideoxy-4-base-6-amino-2,5-anhydro-L-mannitols
作者: Wang, Fang; Yang, Zhen-Jun; Jin, Hong-Wei; Zhang, Liang-Ren; Zhang, He
刊名: TETRAHEDRON-ASYMMETRY
发表日期: 2007-09-17
DOI: 10.1016/j.tetasy.2007.08.032
卷: 18, 期:18, 页:2139-2146
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical
研究领域[WOS]: Chemistry
关键词[WOS]: ANTI-HIV AGENTS ; OLIGONUCLEOTIDES ; ISONUCLEOSIDES ; NUCLEOSIDES ; ANALOGS ; DNA ; OLIGODEOXYNUCLEOTIDES ; TRIPHOSPHATES ; RECOGNITION ; DERIVATIVES
英文摘要:

3,6-Di-O-methanesulfonyl-2,5-anhydro-L-idofuranose dimethyl acetal 9 was reacted with NaN3 in DMF to give 6-azido substituted carbohydrate 10 selectively. A series of 6-amino-isonucleosides 4a-d were synthesized by the reaction of nucleobases with epoxide 13, followed by hydrolysis, reduction, and deprotection, in good yield. (c) 2007 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000252095200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55385
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Fang,Yang, Zhen-Jun,Jin, Hong-Wei,et al. A concise synthesis of 4,6-dideoxy-4-base-6-amino-2,5-anhydro-L-mannitols[J]. TETRAHEDRON-ASYMMETRY,2007,18(18):2139-2146.
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