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IR@PKUHSC  > 北京大学临床肿瘤学院  > 遗传学研究室  > 期刊论文
学科主题: 临床医学
题名:
Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009-2011
作者: Hang, Dong1; Liu, Fangfang1; Liu, Mengfei1; He, Zhonghu1; Sun, Min1; Liu, Ying1; Li, Jingjing1; Pan, Yaqi1; Ning, Tao1; Guo, Chuanhai1; Liang, Yongmei1; Xu, Ruiping2; Zhang, Lixin2; Cai, Hong1; Ke, Yang1
刊名: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
发表日期: 2014-10-01
DOI: 10.1158/1055-9965.EPI-14-0084
卷: 23, 期:10, 页:2101-2110
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: OROPHARYNGEAL CANCER ; HPV INFECTION ; UNITED-STATES ; NECK CANCERS ; GENOMIC DNA ; YOUNG MEN ; PREVALENCE ; HEAD ; WORLDWIDE ; WOMEN
英文摘要:

Background: Despite the established link between oral human papillomavirus (HPV) infection and a subset of oropharyngeal squamous cell carcinoma (OSCC), little is known about the epidemiology of oral HPV infection among healthy adults in China.

Methods: Oral swab specimens and questionnaires were collected from 5,410 individuals (ages 25-65 years). HPV DNA in oral exfoliated cells was tested by general primer-mediated (SPF1/GP6+) PCR and sequencing. Univariate and multivariate analyses were performed to assess the associations between exposure factors and oral infection.

Results: Alpha mucosal HPV types were detected in 0.67% [95% confidence interval (CI), 0.47%-0.93%] of 5,351 beta-globin-positive specimens, and cutaneous HPV in 5.46% (95% CI, 4.86%-6.10%). HPV16 and 3 were the most prevalent types of a mucosal (0.43%; 95% CI, 0.27%-0.64%) and cutaneous HPV (4.17%; 95% CI, 3.65%-4.74%), respectively. The prevalence of a mucosal HPV decreased with increasing age (25-65 years) from 0.93% to 0.36% (P-trend = 0.033), and was associated with self-reported history of oral disease [adjusted odds ratio (OR), 4.78; 95% CI, 1.07-21.41]. In 1,614 heterosexual couples, cutaneous HPV in one partner was found to increase the other partner′s risk of cutaneous HPV infection (adjusted OR, 2.33; 95% CI, 1.22-4.48).

Conclusions: Oral HPV infection, particularly with a mucosal types, is rare among healthy adults in China. A younger age and a history of oral disease imply higher risk of a mucosal HPV infection.

Impact: This study addresses the paucity of epidemiological data on oral HPV infection among healthy population in China. (C) 2014 AACR.

语种: 英语
所属项目编号: 30872937 ; 30930102 ; 2011CB504300 ; 2012CB910800 ; 201202014 ; 200902002 ; 7100001
项目资助者: Natural Science Foundation of China ; "973" Project of National Ministry of Science and Technology Grant ; Charity Project of National Ministry of Health ; Natural Science Foundation of Beijing
WOS记录号: WOS:000345277400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55388
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Anyang Canc Hosp, Anyang, Henan, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Genet Lab, Minist Educ,Canc Hosp & Inst, Beijing 100042, Peoples R China

Recommended Citation:
Hang, Dong,Liu, Fangfang,Liu, Mengfei,et al. Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009-2011[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2014,23(10):2101-2110.
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