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学科主题: 公共卫生
题名:
LONG-TERM ADMINISTRATION OF GREEN TEA CATECHINS PREVENTS AGE-RELATED SPATIAL LEARNING AND MEMORY DECLINE IN C57BL/6 J MICE BY REGULATING HIPPOCAMPAL CYCLIC AMP-RESPONSE ELEMENT BINDING PROTEIN SIGNALING CASCADE
作者: Li, Q.1; Zhao, H. F.1; Zhang, Z. F.1; Liu, Z. G.1; Pei, X. R.1; Wang, J. B.1; Cai, M. Y.2; Li, Y.1
关键词: green tea catechins ; learning and memory ; Morris water maze ; CREB ; BDNF ; Bcl-2
刊名: NEUROSCIENCE
发表日期: 2009-04-10
DOI: 10.1016/j.neuroscience.2009.02.008
卷: 159, 期:4, 页:1208-1215
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: FAMILY TRANSCRIPTION FACTOR ; NEUROTROPHIC FACTOR ; NEURODEGENERATIVE DISEASES ; CREB PHOSPHORYLATION ; POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE ; SYNAPTIC PLASTICITY ; NERVOUS-SYSTEM ; DENTATE GYRUS ; LATE-PHASE ; IN-VIVO
英文摘要:

Flavonoid-rich foods have been shown to be effective at reversing age-related deficits in learning and memory in both animals and humans. However, little investigation of the preventative effects of flavonoids on the naturally aged animals was reported. In our study, 14-month-old female C57BL/6 J mice were orally administered 0.025%, 0.05% and 0.1% green tea catechins (GTC, w/v) in drinking water for 6 months; we found that a supplementation with 0.05% or 0.1% GTC prevented age-related spatial learning and memory decline of mice in the Morris water maze. Better performance of GTC-treated mice was associated with increased levels of cAMP-response element binding protein (CREB) phosphorylation in the hippocampus. The expressions of brain-derived neurotrophic factor (BDNF) and Bcl-2, two target genes of CREB which can exhibit long-term regulatory roles in synaptic plasticity and synaptic structure, were also increased. We also found that long-term 0.05% or 0.1% GTC administration prevented age-related reductions of two representative postsynaptic density proteins PSD95 and Ca(2+)/calmodulin-dependent protein kinase 11, suggesting that synaptic structural changes may be involved. These results demonstrated that long-term 0.05% or 0.1% green tea catechin administration may prevent age-related spatial learning and memory decline of female C57BL/6 J mice by regulating hippocampal CREB signaling cascade. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000265129800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55394
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing 100191, Peoples R China
2.China Natl Res Inst Food & Fermentat Ind, Beijing 100027, Peoples R China

Recommended Citation:
Li, Q.,Zhao, H. F.,Zhang, Z. F.,et al. LONG-TERM ADMINISTRATION OF GREEN TEA CATECHINS PREVENTS AGE-RELATED SPATIAL LEARNING AND MEMORY DECLINE IN C57BL/6 J MICE BY REGULATING HIPPOCAMPAL CYCLIC AMP-RESPONSE ELEMENT BINDING PROTEIN SIGNALING CASCADE[J]. NEUROSCIENCE,2009,159(4):1208-1215.
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