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学科主题: 临床医学
题名:
Efficacy and Tolerability of a Single-Pill Combination of Amlodipine/Valsartan in Asian Hypertensive Patients Not Adequately Controlled with Valsartan Monotherapy
作者: Huang, Jun2; Sun, Ning-Ling3; Hao, Yu-Ming4; Zhu, Jun-Ren1; Tu, Yingmei5; Curt, Valentin6; Zhang, Ying6; Trial Investigators
关键词: valsartan ; amlodipine ; Asian ; single-pill ; hypertension
刊名: CLINICAL AND EXPERIMENTAL HYPERTENSION
发表日期: 2011
DOI: 10.3109/10641963.2010.531849
卷: 33, 期:3, 页:179-186
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Peripheral Vascular Disease
研究领域[WOS]: Pharmacology & Pharmacy ; Cardiovascular System & Cardiology
关键词[WOS]: BLOOD-PRESSURE ; 5 MG ; THERAPY ; RISK
英文摘要:

This randomized, double-blind study evaluated efficacy of a single-pill combination of amlodipine/valsartan (Aml/Val) in Asian patients with hypertension not responding to Val 80 mg. Patients with mean sitting diastolic blood pressure (DBP) >= 90 - <= 110 mmHg were randomized to Aml/Val 5/80, Val 80, or Val 160 mg for 8 weeks. At week-8 endpoint, significantly greater reductions in BP were seen with Aml/Val 5/80 mg than valsartan monotherapies (p < 0.0001). The BP control was greater with Aml/Val 5/80 (70.5%) than Val (44.1-58.6%) monotherapies. The combination was well tolerated. In conclusion, single-pill combination with Aml/Val provided significant additional BP reduction and control in hypertensive patients not responding to Val 80 mg.

语种: 英语
项目资助者: Novartis Pharma AG, Basel, Switzerland
WOS记录号: WOS:000289894600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55398
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Hebei Med Univ, Hosp 2, Shijiazhuang, Peoples R China
3.Beijing Novartis Pharma Co Ltd, Beijing, Peoples R China
4.Novartis Pharmaceut, E Hanover, NJ USA
5.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China
6.Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China

Recommended Citation:
Huang, Jun,Sun, Ning-Ling,Hao, Yu-Ming,et al. Efficacy and Tolerability of a Single-Pill Combination of Amlodipine/Valsartan in Asian Hypertensive Patients Not Adequately Controlled with Valsartan Monotherapy[J]. CLINICAL AND EXPERIMENTAL HYPERTENSION,2011,33(3):179-186.
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