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Efficacy and Tolerability of a Single-Pill Combination of Amlodipine/Valsartan in Asian Hypertensive Patients Not Adequately Controlled with Valsartan Monotherapy
Huang, Jun2; Sun, Ning-Ling3; Hao, Yu-Ming4; Zhu, Jun-Ren1; Tu, Yingmei5; Curt, Valentin6; Zhang, Ying6; Trial Investigators
关键词Valsartan Amlodipine Asian Single-pill Hypertension
刊名CLINICAL AND EXPERIMENTAL HYPERTENSION
2011
DOI10.3109/10641963.2010.531849
33期:3页:179-186
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Peripheral Vascular Disease
研究领域[WOS]Pharmacology & Pharmacy ; Cardiovascular System & Cardiology
关键词[WOS]BLOOD-PRESSURE ; 5 MG ; THERAPY ; RISK
英文摘要

This randomized, double-blind study evaluated efficacy of a single-pill combination of amlodipine/valsartan (Aml/Val) in Asian patients with hypertension not responding to Val 80 mg. Patients with mean sitting diastolic blood pressure (DBP) >= 90 - <= 110 mmHg were randomized to Aml/Val 5/80, Val 80, or Val 160 mg for 8 weeks. At week-8 endpoint, significantly greater reductions in BP were seen with Aml/Val 5/80 mg than valsartan monotherapies (p < 0.0001). The BP control was greater with Aml/Val 5/80 (70.5%) than Val (44.1-58.6%) monotherapies. The combination was well tolerated. In conclusion, single-pill combination with Aml/Val provided significant additional BP reduction and control in hypertensive patients not responding to Val 80 mg.

语种英语
WOS记录号WOS:000289894600007
资助机构Novartis Pharma AG, Basel, Switzerland
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55398
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Hebei Med Univ, Hosp 2, Shijiazhuang, Peoples R China
3.Beijing Novartis Pharma Co Ltd, Beijing, Peoples R China
4.Novartis Pharmaceut, E Hanover, NJ USA
5.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China
6.Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Peoples R China
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GB/T 7714
Huang, Jun,Sun, Ning-Ling,Hao, Yu-Ming,et al. Efficacy and Tolerability of a Single-Pill Combination of Amlodipine/Valsartan in Asian Hypertensive Patients Not Adequately Controlled with Valsartan Monotherapy[J]. CLINICAL AND EXPERIMENTAL HYPERTENSION,2011,33(3):179-186.
APA Huang, Jun.,Sun, Ning-Ling.,Hao, Yu-Ming.,Zhu, Jun-Ren.,Tu, Yingmei.,...&Trial Investigators.(2011).Efficacy and Tolerability of a Single-Pill Combination of Amlodipine/Valsartan in Asian Hypertensive Patients Not Adequately Controlled with Valsartan Monotherapy.CLINICAL AND EXPERIMENTAL HYPERTENSION,33(3),179-186.
MLA Huang, Jun,et al."Efficacy and Tolerability of a Single-Pill Combination of Amlodipine/Valsartan in Asian Hypertensive Patients Not Adequately Controlled with Valsartan Monotherapy".CLINICAL AND EXPERIMENTAL HYPERTENSION 33.3(2011):179-186.
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