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学科主题: 药学
题名:
Research on the in vitro anticancer activity and in vivo tissue distribution of Amoitone B nanocrystals
作者: Hao, Leilei1; Luan, Jingjing1; Zhang, Dianrui1; Li, Caiyun1; Guo, Hejian1; Qi, Lisi1; Liu, Xinquan1; Li, Tingting1; Zhang, Qiang2
关键词: Amoitone B ; Nanocrystals ; Cytotoxicity ; Flow cytometry ; Tissue distribution
刊名: COLLOIDS AND SURFACES B-BIOINTERFACES
发表日期: 2014-05-01
DOI: 10.1016/j.colsurfb.2014.02.042
卷: 117, 页:258-266
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]: Biophysics ; Chemistry ; Materials Science
关键词[WOS]: FOLLICLE-ASSOCIATED EPITHELIUM ; NANOSTRUCTURED LIPID CARRIERS ; ORPHAN-RECEPTOR NUR77 ; GASTRIC-CANCER CELLS ; PARENTERAL DELIVERY ; PARTICLE-SIZE ; NANOSUSPENSION ; NANOPARTICLES ; FORMULATION ; TRANSPORT
英文摘要:

Amoitone B, a natural agonist to Nur77, is a promising anticancer drug. However, its application is seriously restricted due to the water-insolubility and short biological half-life. Amoitone B nanocrystals (AmB-NC) were formulated by microfluidization method to overcome the above obstacles. This study aims to evaluate the cytotoxicity and tissue distribution of AmB-NC. MIT [3-(4,5-dimethylthiazol-2-y1)2,5-diphenyltetrazolium bromide] assay revealed the improved in vitro antitumor activity of AmB-NC against stomach, colon, liver and lung cancer cells compared with Amoitone B solution. Meanwhile, observation of morphological changes, cell cycle and apoptosis examination using flow cytometry exhibited that AmB-NC could induce G1 cycle arrest and markedly enhance the apoptosis of human gastric cancer BGC-823 cell line. Tissue distribution study demonstrated that AmB-NC had a higher distribution in liver and lung, which was helpful for relevant cancer treatment. In conclusion, AmB-NC could be a potential delivery system for treatment of human cancer. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300
项目资助者: National Basic Research Program of China
WOS记录号: WOS:000336018700035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55400
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Hao, Leilei,Luan, Jingjing,Zhang, Dianrui,et al. Research on the in vitro anticancer activity and in vivo tissue distribution of Amoitone B nanocrystals[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2014,117:258-266.
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