北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 内分泌科  > 期刊论文
学科主题: 临床医学
题名:
Worse Pancreatic beta-cell Function and Better Insulin Sensitivity in Older Chinese Without Diabetes
作者: Xiao, Jianzhong1; Weng, Jianping2; Ji, Linong3; Jia, Weiping4; Lu, Juming5; Shan, Zhongyan6; Liu, Jie7; Tian, Haoming8; Ji, Qiuhe9; Yang, Zhaojun1; Yang, Wenying1; China Natl Diabet Metab Disorders
关键词: Insulin sensitivity ; Insulin release ; Oral glucose tolerance ; Age
刊名: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
发表日期: 2014-04-01
DOI: 10.1093/gerona/glt104
卷: 69, 期:4, 页:463-470
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Geriatrics & Gerontology ; Gerontology
研究领域[WOS]: Geriatrics & Gerontology
关键词[WOS]: IMPAIRED GLUCOSE-TOLERANCE ; FASTING GLUCOSE ; ASIAN COHORTS ; AGE ; INTOLERANCE ; DYSFUNCTION ; RESISTANCE ; SECRETION ; PATHOGENESIS ; PREVALENCE
英文摘要:

Background. Whether insulin secretion and insulin sensitivity in older Chinese differ from younger persons without diabetes has not been examined and is unknown to us.

Methods. Oral glucose tolerance test was performed in a total of 32,245 Chinese without diabetes history. Insulin sensitivity was estimated by Matsuda′s insulin sensitivity index (Matsuda ISI), and insulin secretion was measured by the insulinogenic index. The insulin secretion and sensitivity were compared among three age groups: 20-39 (the young), 40-59 (the middle), and greater than or equal to 60 years (the older).

Results. A higher proportion of postchallenge hyperglycemia (PH), both in prediabetes and in diabetes stage, was associated with older age. In the young, middle, and older age groups, the insulinogenic index median was 10.64, 8.40, and 6.67, respectively, in individuals with normal glucose tolerance (NGT); it was 8.56, 6.12, and 4.98 in individuals with prediabetes, respectively (p < .001 vs the young group). In these three age groups, the Matsuda insulin sensitivity index was 8.20, 8.39, and 8.84 in individuals with normal glucose tolerance, and it was 5.23, 5.94, and 6.33 in individuals with prediabetes, respectively (p < .05 vs the young group). These differences were independent of body mass index and waist circumference.

Conclusions. Older Chinese without diabetes are characterized with worse insulin secretion and better insulin sensitivity. Insulin insufficiency and insulin resistance may contribute disproportionately to abnormal glucose tolerance in people of different age.

语种: 英语
所属项目编号: 07020470055
项目资助者: Foundation of Chinese Medical Association
WOS记录号: WOS:000333385500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55405
Appears in Collections:北京大学第二临床医学院_内分泌科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.China Japan Friendship Hosp, Dept Endocrinol, Beijing 100029, Peoples R China
2.Sun Yat Sen Univ, Hosp 3, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol, Shanghai, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
6.Chinese Med Univ, Affiliated Hosp 1, Dept Endocrinol, Liaoning, Peoples R China
7.Shanxi Prov Peoples Hosp, Dept Endocrinol, Taiyuan, Peoples R China
8.Sichuan Univ, West China Hosp, Dept Endocrinol, Chengdu, Sichuan, Peoples R China
9.Fourth Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian, Shaanxi, Peoples R China

Recommended Citation:
Xiao, Jianzhong,Weng, Jianping,Ji, Linong,et al. Worse Pancreatic beta-cell Function and Better Insulin Sensitivity in Older Chinese Without Diabetes[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2014,69(4):463-470.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xiao, Jianzhong]'s Articles
[Weng, Jianping]'s Articles
[Ji, Linong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xiao, Jianzhong]‘s Articles
[Weng, Jianping]‘s Articles
[Ji, Linong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace