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学科主题临床医学
Worse Pancreatic beta-cell Function and Better Insulin Sensitivity in Older Chinese Without Diabetes
Xiao, Jianzhong1; Weng, Jianping2; Ji, Linong3; Jia, Weiping4; Lu, Juming5; Shan, Zhongyan6; Liu, Jie7; Tian, Haoming8; Ji, Qiuhe9; Yang, Zhaojun1; Yang, Wenying1; China Natl Diabet Metab Disorders
关键词Insulin Sensitivity Insulin Release Oral Glucose Tolerance Age
刊名JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
2014-04-01
DOI10.1093/gerona/glt104
69期:4页:463-470
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology ; Gerontology
资助者Foundation of Chinese Medical Association ; Foundation of Chinese Medical Association
研究领域[WOS]Geriatrics & Gerontology
关键词[WOS]IMPAIRED GLUCOSE-TOLERANCE ; FASTING GLUCOSE ; ASIAN COHORTS ; AGE ; INTOLERANCE ; DYSFUNCTION ; RESISTANCE ; SECRETION ; PATHOGENESIS ; PREVALENCE
英文摘要

Background. Whether insulin secretion and insulin sensitivity in older Chinese differ from younger persons without diabetes has not been examined and is unknown to us.

Methods. Oral glucose tolerance test was performed in a total of 32,245 Chinese without diabetes history. Insulin sensitivity was estimated by Matsuda′s insulin sensitivity index (Matsuda ISI), and insulin secretion was measured by the insulinogenic index. The insulin secretion and sensitivity were compared among three age groups: 20-39 (the young), 40-59 (the middle), and greater than or equal to 60 years (the older).

Results. A higher proportion of postchallenge hyperglycemia (PH), both in prediabetes and in diabetes stage, was associated with older age. In the young, middle, and older age groups, the insulinogenic index median was 10.64, 8.40, and 6.67, respectively, in individuals with normal glucose tolerance (NGT); it was 8.56, 6.12, and 4.98 in individuals with prediabetes, respectively (p < .001 vs the young group). In these three age groups, the Matsuda insulin sensitivity index was 8.20, 8.39, and 8.84 in individuals with normal glucose tolerance, and it was 5.23, 5.94, and 6.33 in individuals with prediabetes, respectively (p < .05 vs the young group). These differences were independent of body mass index and waist circumference.

Conclusions. Older Chinese without diabetes are characterized with worse insulin secretion and better insulin sensitivity. Insulin insufficiency and insulin resistance may contribute disproportionately to abnormal glucose tolerance in people of different age.

语种英语
所属项目编号07020470055
资助者Foundation of Chinese Medical Association ; Foundation of Chinese Medical Association
WOS记录号WOS:000333385500011
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55405
专题北京大学第二临床医学院_内分泌科
作者单位1.China Japan Friendship Hosp, Dept Endocrinol, Beijing 100029, Peoples R China
2.Sun Yat Sen Univ, Hosp 3, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol, Shanghai, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
6.Chinese Med Univ, Affiliated Hosp 1, Dept Endocrinol, Liaoning, Peoples R China
7.Shanxi Prov Peoples Hosp, Dept Endocrinol, Taiyuan, Peoples R China
8.Sichuan Univ, West China Hosp, Dept Endocrinol, Chengdu, Sichuan, Peoples R China
9.Fourth Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian, Shaanxi, Peoples R China
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GB/T 7714
Xiao, Jianzhong,Weng, Jianping,Ji, Linong,et al. Worse Pancreatic beta-cell Function and Better Insulin Sensitivity in Older Chinese Without Diabetes[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,2014,69(4):463-470.
APA Xiao, Jianzhong.,Weng, Jianping.,Ji, Linong.,Jia, Weiping.,Lu, Juming.,...&China Natl Diabet Metab Disorders.(2014).Worse Pancreatic beta-cell Function and Better Insulin Sensitivity in Older Chinese Without Diabetes.JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES,69(4),463-470.
MLA Xiao, Jianzhong,et al."Worse Pancreatic beta-cell Function and Better Insulin Sensitivity in Older Chinese Without Diabetes".JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 69.4(2014):463-470.
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