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学科主题基础医学
Girdin correlated with autophagy in invasive ductal breast carcinomas
Jiang, Ping1,2; Cui, Su-Ping3; Ren, Ya-Li4; Mao, Jing-Zhuo3; Liu, Hai-Jing3; Tian, Yuan3; Liu, Jian-Ying3; Du, Juan3; Hou, Lin3; Zhang, Bo3
关键词Autophagy Breast Carcinoma Girdin Lc3-ii
刊名TUMORI
2013-07-01
99期:4页:530-534
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation
研究领域[WOS]Oncology
关键词[WOS]CANCER ; EXPRESSION ; PROTEIN ; INHIBITION ; CELLS ; RESISTANCE ; TISSUES
英文摘要

Aims and background. Increasing evidence claims that autophagy is essential for breast cancer progression. Girdin was found highly expressed in breast cancers. It has been reported that Girdin attenuates autophagy in HeLa cells. We explored the relationship between Girdin expression and autophagic patterns in breast cancer.

Methods and study design. In the study, Girdin expression and autophagic activity were investigated in a series of 99 invasive ductal breast carcinomas after immuno-histochemical staining for the autophagy-associated proteins LC3-II and Girdin.

Results. The level of Girdin expression negatively correlated with LC3-II level, which represents autophagic activity (r = -0.289), and positively correlated with lymph node metastasis (r = 0.472). Girdin level was found no different in the "diffuse cytoplasmic" and "stone-like" patterns of LC3-II.

Conclusions. Up-regulated autophagy was negatively associated with Girdin level. There was a significant correlation between Girdin expression and lymph nodes metastasis in invasive ductal breast carcinoma.

语种英语
所属项目编号30770830 ; 81072172 ; 20100470170 ; 201104043
资助者National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation
WOS记录号WOS:000329001000015
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55412
专题基础医学院_病理学系
作者单位1.Minist Hlth, Beijing Inst Geriatr, Beijing 100730, Peoples R China
2.Minist Hlth, Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Electron Microscopy Lab, Beijing 100871, Peoples R China
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GB/T 7714
Jiang, Ping,Cui, Su-Ping,Ren, Ya-Li,et al. Girdin correlated with autophagy in invasive ductal breast carcinomas[J]. TUMORI,2013,99(4):530-534.
APA Jiang, Ping.,Cui, Su-Ping.,Ren, Ya-Li.,Mao, Jing-Zhuo.,Liu, Hai-Jing.,...&Zhang, Bo.(2013).Girdin correlated with autophagy in invasive ductal breast carcinomas.TUMORI,99(4),530-534.
MLA Jiang, Ping,et al."Girdin correlated with autophagy in invasive ductal breast carcinomas".TUMORI 99.4(2013):530-534.
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