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学科主题: 基础医学
题名:
Girdin correlated with autophagy in invasive ductal breast carcinomas
作者: Jiang, Ping1,2; Cui, Su-Ping3; Ren, Ya-Li4; Mao, Jing-Zhuo3; Liu, Hai-Jing3; Tian, Yuan3; Liu, Jian-Ying3; Du, Juan3; Hou, Lin3; Zhang, Bo3
关键词: autophagy ; breast carcinoma ; Girdin ; LC3-II
刊名: TUMORI
发表日期: 2013-07-01
卷: 99, 期:4, 页:530-534
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CANCER ; EXPRESSION ; PROTEIN ; INHIBITION ; CELLS ; RESISTANCE ; TISSUES
英文摘要:

Aims and background. Increasing evidence claims that autophagy is essential for breast cancer progression. Girdin was found highly expressed in breast cancers. It has been reported that Girdin attenuates autophagy in HeLa cells. We explored the relationship between Girdin expression and autophagic patterns in breast cancer.

Methods and study design. In the study, Girdin expression and autophagic activity were investigated in a series of 99 invasive ductal breast carcinomas after immuno-histochemical staining for the autophagy-associated proteins LC3-II and Girdin.

Results. The level of Girdin expression negatively correlated with LC3-II level, which represents autophagic activity (r = -0.289), and positively correlated with lymph node metastasis (r = 0.472). Girdin level was found no different in the "diffuse cytoplasmic" and "stone-like" patterns of LC3-II.

Conclusions. Up-regulated autophagy was negatively associated with Girdin level. There was a significant correlation between Girdin expression and lymph nodes metastasis in invasive ductal breast carcinoma.

语种: 英语
所属项目编号: 30770830 ; 81072172 ; 20100470170 ; 201104043
项目资助者: National Natural Science Foundation of China ; China Postdoctoral Science Foundation
WOS记录号: WOS:000329001000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55412
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Minist Hlth, Beijing Inst Geriatr, Beijing 100730, Peoples R China
2.Minist Hlth, Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Electron Microscopy Lab, Beijing 100871, Peoples R China

Recommended Citation:
Jiang, Ping,Cui, Su-Ping,Ren, Ya-Li,et al. Girdin correlated with autophagy in invasive ductal breast carcinomas[J]. TUMORI,2013,99(4):530-534.
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