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学科主题基础医学
Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea
Zou Xia-Juan1; Zhang Shi-Wei2; Liu Ying2; Liu Zheng-Ming2; Gao Jun-Wei3; Song Qian-Liu3; Pan Yan3; Zhang Jian-Zhao3; Li Xue-Jun3
关键词Crystal Structure Anti-tumor Metastasis Lewis-lung-carcinoma Model 2-amino-1 Synthesis 3 4-thiadiazole Derivatives
刊名CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
2011
30期:7页:1001-1005
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear ; Crystallography
研究领域[WOS]Chemistry ; Crystallography
关键词[WOS]ANTI-TUMOR ACTIVITY ; PHASE-II TRIAL ; 2-ACYLAMINO-1,3,4-THIADIAZOLES ; 2-AMINO-1,3,4-THIADIAZOLE ; AMINOTHIADIAZOLE
英文摘要

The title compound N-1-(1,3,4-thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea (C9H7N4OSCl, M-r = 254.70) was prepared by the reaction of m-chlorophenyl isocyanate with 2-amino-1,3,4-thiadiazole in dry acetonitrile. The effect of the title compound on tumor metastasis was analyzed by Lewis-lung-carcinoma model. The bioassay showed that the title compound significantly reduced the number of lung metastasis. The crystal structure has been determined by X-ray diffraction. The crystal belongs to the monoclinic system, space group P2(1)/c with a = 11.565(2), b = 9.5616(19), c = 10.221(2) angstrom, beta = 111.75(3)degrees, Z = 4, V = 1049.8(4) angstrom(3), D-c = 1.612 Mg/m(3), F(000) = 520, mu(MoKa) = 0.544 mm(-1), R = 0.0468 and wR = 0.0922 for 1236 observed reflections (I > 2 sigma(I)).

语种英语
WOS记录号WOS:000293676600011
项目编号2001AA23561
资助机构863 high technology program
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55416
专题北京大学基础医学院
北京大学医学信息学中心
作者单位1.Peking Univ, Med & Healthy Analyt Ctr, Prote Lab, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
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GB/T 7714
Zou Xia-Juan,Zhang Shi-Wei,Liu Ying,et al. Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2011,30(7):1001-1005.
APA Zou Xia-Juan.,Zhang Shi-Wei.,Liu Ying.,Liu Zheng-Ming.,Gao Jun-Wei.,...&Li Xue-Jun.(2011).Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,30(7),1001-1005.
MLA Zou Xia-Juan,et al."Anti-tumor Metastasis and Crystal Structure of N-1-(1,3,4-Thiadiazole-2-yl)-N-3-m-chlorobenzoyl-urea".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 30.7(2011):1001-1005.
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