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学科主题临床医学
Quantitative Measurement of Oxygen Extraction Fraction by MRI in Patients with Cerebrovascular Disease: Pre- and Post-Surgery
Xie, Sheng1; Xia, Jiangxi2; Duan, Hongzhou3; Fu, Lei1; Mo, Dapeng4; Zhang, Xiaodong2
关键词Oxygen Extraction Fraction (Oef) Cerebral Blood Flow (Cbf) Magnetic Resonance Imaging (Mri) Stent Superficial Temporal Artery-middle Cerebral Artery (Sta-mca) Bypass
刊名TURKISH NEUROSURGERY
2015
DOI10.5137/1019-5149.JTN.8987-13.1
25期:1页:21-28
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Surgery
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Neurosciences & Neurology ; Surgery
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; MIDDLE CEREBRAL-ARTERY ; EXTRACRANIAL-INTRACRANIAL BYPASS ; DETECTING MISERY PERFUSION ; CAROTID OCCLUSION ; BLOOD-FLOW ; PET ; ACETAZOLAMIDE ; HEMODYNAMICS ; TERRITORIES
英文摘要

AIM: We aimed to evaluate cerebral hemodynamic status of preoperative and postoperative revascularization treatment by oxygen extraction fraction (OEF)-magnetic resonance imaging (MRI) in patients with severe cerebrovascular stenosis or occlusive disease.

MATERIAL and METHODS: This study enrolled 9 symptomatic patients with severe cerebrovascular disease and 9 age-matched normal volunteers. Cerebral blood flow (CBF) and OEF were determined in all subjects by functional MRI. Brain regions with elevated OEF above normal range were defined in the patients preoperatively. The values of pre- and postoperative OEF in these regions were compared.

RESULTS: A total of 16 regions of interest (ROIs) had elevated OEF before the vascular surgery, with relative CBF (rCBF) values ranging from 0.2 to 1.0. OEF decreased to normal range in 15 ROls postoperatively, which indicated hemodynamic improvement in these regions. The OEF value of the high-OEF group (preoperative OEF value ranged from 0.365 to 0.400) had a significant decrease compared with those of the low-OEF group (preoperative OEF value ranged from 0.350 to 0.365), which showed an a statistical difference (p = 0.001).

CONCLUSION: OEF was elevated in patients with severe ischemic cerebrovascular disease, and decreased after successful revascularization. OEF-MRI can provide quantitative information for evaluating the hemodynamic status and selecting the candidates suitable for revascularization.

语种英语
所属项目编号81201154
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000349275700005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55417
专题北京大学第一临床医学院_放射治疗科
作者单位1.China Japan Friendship Hosp, Dept Radiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Neurosurg, Beijing 100871, Peoples R China
4.Beijing Tiantan Hosp, Dept Emergency Intervent Neuroradiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Xie, Sheng,Xia, Jiangxi,Duan, Hongzhou,et al. Quantitative Measurement of Oxygen Extraction Fraction by MRI in Patients with Cerebrovascular Disease: Pre- and Post-Surgery[J]. TURKISH NEUROSURGERY,2015,25(1):21-28.
APA Xie, Sheng,Xia, Jiangxi,Duan, Hongzhou,Fu, Lei,Mo, Dapeng,&Zhang, Xiaodong.(2015).Quantitative Measurement of Oxygen Extraction Fraction by MRI in Patients with Cerebrovascular Disease: Pre- and Post-Surgery.TURKISH NEUROSURGERY,25(1),21-28.
MLA Xie, Sheng,et al."Quantitative Measurement of Oxygen Extraction Fraction by MRI in Patients with Cerebrovascular Disease: Pre- and Post-Surgery".TURKISH NEUROSURGERY 25.1(2015):21-28.
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