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学科主题基础医学
Presynaptic Defects Underlying Impaired Learning and Memory Function in Lipoprotein Lipase-Deficient Mice
Xian, Xunde1,2; Liu, Tingting3,4; Yu, Jia3,4; Wang, Yuhui1,2; Miao, Yifei3,4; Zhang, Jianjun5; Yu, Yan3,4; Ross, Colin6; Karasinska, Joanna M.6; Hayden, Michael R.6; Liu, George1,2; Chui, Dehua3,4
刊名JOURNAL OF NEUROSCIENCE
2009-04-08
DOI10.1523/JNEUROSCI.0297-09.2009
29期:14页:4681-4685
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Major National Basic Research Program of the People&prime ; s Republic of China ; Canadian Institutes of Health Research ; National Natural Science Foundation of People&prime ; s Republic of China ; Heart and Stroke Foundation of Canada ; Michael Smith Foundation for Health Research ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Major National Basic Research Program of the People&prime ; s Republic of China ; Canadian Institutes of Health Research ; National Natural Science Foundation of People&prime ; s Republic of China ; Heart and Stroke Foundation of Canada ; Michael Smith Foundation for Health Research
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]LOW-DENSITY-LIPOPROTEIN ; SYNAPTIC VESICLE CYCLE ; ALPHA-TOCOPHEROL ; VITAMIN-E ; TRANSGENIC MICE ; MESSENGER-RNA ; METABOLISM ; DIFFERENTIATION ; LOCALIZATION ; MECHANISM
英文摘要

Lipoprotein lipase (LPL) is predominantly expressed in adipose and muscle where it plays a crucial role in the metabolism of triglyceride-rich plasma lipoproteins. LPL is also expressed in the brain with highest levels found in the pyramidal cells of the hippocampus, suggesting a possible role for LPL in the regulation of cognitive function. However, very little is currently known about the specific role of LPL in the brain. We have generated a mouse model of LPL deficiency which was rescued from neonatal lethality by somatic gene transfer. These mice show no exogenous and endogenous LPL expression in the brain. To study the role of LPL in learning and memory, the performance of LPL-deficient mice was tested in two cognitive tests. In a water maze test, LPL-deficient mice exhibited increased latency to escape platform and increased mistake frequency. Decreased latency to platform in the step-down inhibitory avoidance test was observed, consistent with impaired learning and memory in these mice. Transmission electron microscopy revealed a significant decrease in the number of presynaptic vesicles in the hippocampus of LPL-deficient mice. The levels of the presynaptic marker synaptophysin were also reduced in the hippocampus, whereas postsynaptic marker postsynaptic density protein 95 levels remained unchanged in LPL-deficient mice. Theses findings indicate that LPL plays an important role in learning and memory function possibly by influencing presynaptic function.

语种英语
所属项目编号30570533 ; 30670414 ; 2006CB500705 ; 0060102A4031 ; G2006CD503801 ; 30821001
资助者National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Major National Basic Research Program of the People&prime ; s Republic of China ; Canadian Institutes of Health Research ; National Natural Science Foundation of People&prime ; s Republic of China ; Heart and Stroke Foundation of Canada ; Michael Smith Foundation for Health Research ; National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Major National Basic Research Program of the People&prime ; s Republic of China ; Canadian Institutes of Health Research ; National Natural Science Foundation of People&prime ; s Republic of China ; Heart and Stroke Foundation of Canada ; Michael Smith Foundation for Health Research
WOS记录号WOS:000265009600034
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55419
专题基础医学院_心血管所
作者单位1.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Key Lab Neurosci,Minist Educ,Minist Publ Hlth, Beijing 100191, Peoples R China
5.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
6.Univ British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Vancouver, BC V5T 4H4, Canada
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Xian, Xunde,Liu, Tingting,Yu, Jia,et al. Presynaptic Defects Underlying Impaired Learning and Memory Function in Lipoprotein Lipase-Deficient Mice[J]. JOURNAL OF NEUROSCIENCE,2009,29(14):4681-4685.
APA Xian, Xunde.,Liu, Tingting.,Yu, Jia.,Wang, Yuhui.,Miao, Yifei.,...&Chui, Dehua.(2009).Presynaptic Defects Underlying Impaired Learning and Memory Function in Lipoprotein Lipase-Deficient Mice.JOURNAL OF NEUROSCIENCE,29(14),4681-4685.
MLA Xian, Xunde,et al."Presynaptic Defects Underlying Impaired Learning and Memory Function in Lipoprotein Lipase-Deficient Mice".JOURNAL OF NEUROSCIENCE 29.14(2009):4681-4685.
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