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学科主题临床医学
High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers
Li, Zhi2,3; Zhang, Wei4; Shao, Yong1,5; Zhang, Chao1; Wu, Qi1; Yang, Hong5; Wan, Xiangbin3; Zhang, Jie5; Guan, Ming6; Wan, Jun1,7; Yu, Bo1,5
关键词Adamts18 Methylation Hrm Gastric Cancer Colorectal Cancer Pancreatic Cancer
刊名MEDICAL ONCOLOGY
2010-09-01
DOI10.1007/s12032-009-9323-8
27期:3页:998-1004
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]DNA METHYLATION ; EMERGING ROLES ; CELL-LINES ; PCR BIAS ; FAMILY ; GENE ; METALLOPROTEINASES ; NASOPHARYNGEAL ; IDENTIFICATION ; AGGRECANASE-1
英文摘要

A disintegrin and metalloprotease with trombo-spondin motifs (ADAMTS) is a family of proteins characterized by the presence of a metalloproteinase domain linked to a variety of specialized ancillary domains. ADAMTS18 is a putative tumor suppressive gene related to nasopharyngeal carcinoma. We used high-resolution melting (HRM) analysis to detect the methylation levels of ADAMTS18 gene in 100 gastric cancers, 100 colorectal cancers, 70 pancreatic cancers, and equal number of adjacent normal tissues. The frequency of ADAMTS18 methylation in all three types of cancers was significantly higher than that in normal tissues. Expression levels of ADAMTS18 were inversely correlated with methylation levels. No significant association was found between ADAMTS18 methylation status and TNM staging in the cancers. In summary, epigenetic regulation of ADAMTS18 was associated with carcinogenesis. The application of HRM analysis is a fast and high-throughput way to investigate the epigenetic status of ADAMTS18.

语种英语
WOS记录号WOS:000281522400068
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55420
专题北京大学深圳医院_皮肤性病科
北京大学临床肿瘤学院_护理部
作者单位1.Henan Prov Tumor Hosp, Dept Gen Surg, Zhengzhou, Henan, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China
3.Zhengzhou Univ, Basic Med Coll, Dept Histol & Embryol, Zhengzhou, Henan, Peoples R China
4.Ji Nan Univ, HKUST JNU Joint Lab, Guangzhou, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shen Zhen, Guangdong, Peoples R China
6.Fudan Univ, Huashan Hosp, Cent Lab, Dept Lab Med, Shanghai 200433, Peoples R China
7.Hong Kong Univ Sci & Technol, Dept Biochem, Kowloon, Hong Kong, Peoples R China
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GB/T 7714
Li, Zhi,Zhang, Wei,Shao, Yong,et al. High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers[J]. MEDICAL ONCOLOGY,2010,27(3):998-1004.
APA Li, Zhi.,Zhang, Wei.,Shao, Yong.,Zhang, Chao.,Wu, Qi.,...&Yu, Bo.(2010).High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers.MEDICAL ONCOLOGY,27(3),998-1004.
MLA Li, Zhi,et al."High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers".MEDICAL ONCOLOGY 27.3(2010):998-1004.
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