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学科主题: 临床医学
题名:
High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers
作者: Li, Zhi2,3; Zhang, Wei4; Shao, Yong1,5; Zhang, Chao1; Wu, Qi1; Yang, Hong5; Wan, Xiangbin3; Zhang, Jie5; Guan, Ming6; Wan, Jun1,7; Yu, Bo1,5
关键词: ADAMTS18 ; Methylation ; HRM ; Gastric cancer ; Colorectal cancer ; Pancreatic cancer
刊名: MEDICAL ONCOLOGY
发表日期: 2010-09-01
DOI: 10.1007/s12032-009-9323-8
卷: 27, 期:3, 页:998-1004
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: DNA METHYLATION ; EMERGING ROLES ; CELL-LINES ; PCR BIAS ; FAMILY ; GENE ; METALLOPROTEINASES ; NASOPHARYNGEAL ; IDENTIFICATION ; AGGRECANASE-1
英文摘要:

A disintegrin and metalloprotease with trombo-spondin motifs (ADAMTS) is a family of proteins characterized by the presence of a metalloproteinase domain linked to a variety of specialized ancillary domains. ADAMTS18 is a putative tumor suppressive gene related to nasopharyngeal carcinoma. We used high-resolution melting (HRM) analysis to detect the methylation levels of ADAMTS18 gene in 100 gastric cancers, 100 colorectal cancers, 70 pancreatic cancers, and equal number of adjacent normal tissues. The frequency of ADAMTS18 methylation in all three types of cancers was significantly higher than that in normal tissues. Expression levels of ADAMTS18 were inversely correlated with methylation levels. No significant association was found between ADAMTS18 methylation status and TNM staging in the cancers. In summary, epigenetic regulation of ADAMTS18 was associated with carcinogenesis. The application of HRM analysis is a fast and high-throughput way to investigate the epigenetic status of ADAMTS18.

语种: 英语
WOS记录号: WOS:000281522400068
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55420
Appears in Collections:北京大学深圳医院_皮肤性病科_期刊论文

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作者单位: 1.Henan Prov Tumor Hosp, Dept Gen Surg, Zhengzhou, Henan, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China
3.Zhengzhou Univ, Basic Med Coll, Dept Histol & Embryol, Zhengzhou, Henan, Peoples R China
4.Ji Nan Univ, HKUST JNU Joint Lab, Guangzhou, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shen Zhen, Guangdong, Peoples R China
6.Fudan Univ, Huashan Hosp, Cent Lab, Dept Lab Med, Shanghai 200433, Peoples R China
7.Hong Kong Univ Sci & Technol, Dept Biochem, Kowloon, Hong Kong, Peoples R China

Recommended Citation:
Li, Zhi,Zhang, Wei,Shao, Yong,et al. High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers[J]. MEDICAL ONCOLOGY,2010,27(3):998-1004.
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