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学科主题: 药学
题名:
Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain
作者: Wang, Zhao H.1,3; Wang, Zhan Y.2; Sun, Chang S.1; Wang, Chun Y.2; Jiang, Tong Y.1; Wang, Si L.1
关键词: Nanoparticle ; Brain targeting ; Trimethylated chitosan ; Neuroprotective effects ; Biochemical parameters ; Co-Q(10)
刊名: BIOMATERIALS
发表日期: 2010-02-01
DOI: 10.1016/j.biomaterials.2009.09.104
卷: 31, 期:5, 页:908-915
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: ALZHEIMERS-DISEASE ; MOUSE MODEL ; BARRIER ; NANOPRECIPITATION ; PROTEIN ; CELLS ; MICE ; PLA
英文摘要:

Trimethylated chitosan (TMC) surface-modified poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (TMC/PLGA-NP) were synthesized as a drug carrier for brain delivery. TMC was covalently coupled to the surface of PLGA nanoparticles (PLGA-NP) via a carbodiimide-mediated link. The zeta potential of TMC/ PLGA-NP was about 20 mV with a mean diameter around 150 nm. 6-coumarin loaded PLGA-NP and TMC/PLGA-NP were injected into the caudal vein of mice, and fluorescent microscopy of brain sections showed a higher accumulation of TMC/PLGA-NP in the cortex, paracoele, the third ventricle and choroid plexus epithelium, while no brain uptake of PLGA-NP was observed. There was no pronounced difference in cell viability between TMC/PLGA-NP and PLGA-NP as shown by MTT assay. Behavioral testing showed that the injection of coenzyme Q(10) loaded TMC/PLGA-NP greatly improved memory impairment, restoring it to a normal level, but the efficacy was slight for loaded PLGA-NP, without TMC conjugation. The senile plaque and biochemical parameter tests confirmed the brain-targeted effects of TMC/PLGA-NP. These experiments show that TMC surface-modified nanoparticles are able to cross the blood-brain barrier and appear to be a promising brain drug delivery carrier with low toxicity. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300
项目资助者: National Basic Research Program of China (973 Program)
WOS记录号: WOS:000273946100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55422
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Shenyang Pharmaceut Univ, Dept Pharmaceut, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China
2.China Med Univ, Lab Cell Engn & Cell Therapy, Inst Tissue Engn, Shenyang 110001, Peoples R China
3.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Zhao H.,Wang, Zhan Y.,Sun, Chang S.,et al. Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain[J]. BIOMATERIALS,2010,31(5):908-915.
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