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学科主题: 临床医学
题名:
Novel approaches towards conquering hepatitis B virus infection
作者: Wu, Guo-Yi; Chen, Hong-Song
关键词: hepatitis B virus ; antiviral drugs ; drug evaluation ; immunomodulatory agents ; gene therapy
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2007-02-14
卷: 13, 期:6, 页:830-836
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: TRANSGENIC MICE ; IN-VIVO ; ANTIVIRAL RESISTANCE ; THERAPEUTIC AGENTS ; ALPHA-INTERFERON ; DENDRITIC CELL ; HBV INFECTION ; L-FMAU ; REPLICATION ; INHIBITION
英文摘要:

Currently approved treatments for hepatitis B virus (HBV) infection include the immunomodulatory agent, IFN-alpha, and nucleos(t)ide analogues. Their efficacy is limited by their side effects, as well as the induction of viral mutations that render them less potent. It is thus necessary to develop drugs that target additional viral antigens. Chemicals and biomaterials by unique methods of preventing HBV replication are currently being developed, including novel nucleosides and newly synthesized compounds such as capsid assembling and mRNA transcription inhibitors. Molecular therapies that target different stages of the HBV life cycle will aid current methods to manage chronic hepatitis B (CHB) infection. The use of immunomodulators and gene therapy are also under consideration. This report summarizes the most recent treatment possibilities for CHB infection. Emerging therapies and their potential mechanisms, efficacy, and pitfalls are discussed. (C) 2007 The WJG Press. All rights reserved.

语种: 英语
WOS记录号: WOS:000244879200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55425
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Wu, Guo-Yi,Chen, Hong-Song. Novel approaches towards conquering hepatitis B virus infection[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2007,13(6):830-836.
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