学科主题临床医学
Novel approaches towards conquering hepatitis B virus infection
Wu, Guo-Yi; Chen, Hong-Song
关键词Hepatitis b Virus Antiviral Drugs Drug Evaluation Immunomodulatory Agents Gene Therapy
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2007-02-14
13期:6页:830-836
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]TRANSGENIC MICE ; IN-VIVO ; ANTIVIRAL RESISTANCE ; THERAPEUTIC AGENTS ; ALPHA-INTERFERON ; DENDRITIC CELL ; HBV INFECTION ; L-FMAU ; REPLICATION ; INHIBITION
英文摘要

Currently approved treatments for hepatitis B virus (HBV) infection include the immunomodulatory agent, IFN-alpha, and nucleos(t)ide analogues. Their efficacy is limited by their side effects, as well as the induction of viral mutations that render them less potent. It is thus necessary to develop drugs that target additional viral antigens. Chemicals and biomaterials by unique methods of preventing HBV replication are currently being developed, including novel nucleosides and newly synthesized compounds such as capsid assembling and mRNA transcription inhibitors. Molecular therapies that target different stages of the HBV life cycle will aid current methods to manage chronic hepatitis B (CHB) infection. The use of immunomodulators and gene therapy are also under consideration. This report summarizes the most recent treatment possibilities for CHB infection. Emerging therapies and their potential mechanisms, efficacy, and pitfalls are discussed. (C) 2007 The WJG Press. All rights reserved.

语种英语
WOS记录号WOS:000244879200003
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55425
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Wu, Guo-Yi,Chen, Hong-Song. Novel approaches towards conquering hepatitis B virus infection[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2007,13(6):830-836.
APA Wu, Guo-Yi,&Chen, Hong-Song.(2007).Novel approaches towards conquering hepatitis B virus infection.WORLD JOURNAL OF GASTROENTEROLOGY,13(6),830-836.
MLA Wu, Guo-Yi,et al."Novel approaches towards conquering hepatitis B virus infection".WORLD JOURNAL OF GASTROENTEROLOGY 13.6(2007):830-836.
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