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学科主题口腔医学
Decreased Osteogenesis in Stromal Cells from Radiolucent Zone of Human TMJ Ankylosis
Xiao, E.1; Li, J. -M.1; Yan, Y. -B.4; An, J. -G.1; Duan, D. -H.2; Gan, Y. -H.3; Zhang, Y.1
关键词Bone Non-union Pathogenesis Condyle Fracture Mesenchymal Stem Cells Bone Formation Bone Proliferation
刊名JOURNAL OF DENTAL RESEARCH
2013-05-01
DOI10.1177/0022034513483471
92期:5页:450-455
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]MESENCHYMAL PROGENITOR CELLS ; FRACTURE NON-UNIONS ; TEMPOROMANDIBULAR-JOINT ; STEM-CELLS ; BONY ANKYLOSIS ; OSTEOBLAST DIFFERENTIATION ; GENE-EXPRESSION ; IN-VITRO ; TISSUE ; INDUCTION
英文摘要

We previously hypothesized that the development of traumatic temporomandibular joint (TMJ) ankylosis was similar to that of hypertrophic non-union. Besides similarities in etiology, hypertrophic bone stumps, and long-term development, the radiolucent zone, frequently located in the ankylosed bone, is another common feature. In this study, we demonstrated that the radiolucent zone also contained multilineage potential cells (RZs, radiolucent-zone-related cells) as the non-union tissues. RZs were characterized and compared with mandibular bone marrow stem cells (BMSCs) by analysis of MSC-related markers, colony-forming-unit assays, multipotential differentiation assays, alkaline phosphatase (ALP) activity assays, and cell transplantation in vivo. Both cell types were positive for CD105, CD166, and Stro-1 expression, negative for CD34 and CD45 expression, and exhibited osteogenic, adipogenic, and chondrogenic differentiation potentials. However, compared with mandibular BMSCs, RZs showed lower colony-forming-unit abilities and proliferation rates. The mineralization and bone-forming ability of RZs was weaker than that of mandibular BMSCs, with Runx2 and ALP mRNA expression and ALP activity significantly lower in RZs. All these results suggest that RZs possess the properties of MSCs but lower proliferation and osteogenic differentiation capacity similar to that of stromal cells in hypertrophic non-union tissues.

语种英语
WOS记录号WOS:000317715300010
项目编号81170936
资助机构National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55428
专题北京大学口腔医学院_综合治疗科
北京大学口腔医学院_外科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Gen Dent, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
4.Tianjin Stomatol Hosp, Dept Oral & Maxillofacial Surg, Tianjin, Peoples R China
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GB/T 7714
Xiao, E.,Li, J. -M.,Yan, Y. -B.,et al. Decreased Osteogenesis in Stromal Cells from Radiolucent Zone of Human TMJ Ankylosis[J]. JOURNAL OF DENTAL RESEARCH,2013,92(5):450-455.
APA Xiao, E..,Li, J. -M..,Yan, Y. -B..,An, J. -G..,Duan, D. -H..,...&Zhang, Y..(2013).Decreased Osteogenesis in Stromal Cells from Radiolucent Zone of Human TMJ Ankylosis.JOURNAL OF DENTAL RESEARCH,92(5),450-455.
MLA Xiao, E.,et al."Decreased Osteogenesis in Stromal Cells from Radiolucent Zone of Human TMJ Ankylosis".JOURNAL OF DENTAL RESEARCH 92.5(2013):450-455.
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