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学科主题: 临床医学
题名:
Serum TNF alpha levels in patients with acute graft-versus-host disease after bone marrow transplantation
作者: Huang, XJ; Wan, J; Lu, DP
关键词: acute graft-versus-host disease (aGVHD) ; TNF alpha ; bone marrow transplantation ; infection
刊名: LEUKEMIA
发表日期: 2001-07-01
卷: 15, 期:7, 页:1089-1091
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
英文摘要:

Tumor necrosis factor alpha (TNF alpha) has been implicated in the pathogenesis of graft-versus-host disease (GVHD). In this study, serum levels of TNF alpha were assessed by ELISA in 243 sera samples from 40 patients who had undergone allogeneic bone marrow transplantation (BMT). Serum TNF alpha levels were measured before BMT and at different time points after BMT. The results were correlated with acute GVHD (aGVHD), infection and conditioning regimen. Serum TNF alpha levels were significantly higher in patients with grades II-IV aGVHD than in those with grade 0 or I aGVHD, but there was no clear correlation between serum TNF alpha and severity of aGVHD. Serum TNF alpha levels in infected patients were not statistically different from those in patients without infection. The conditioning regimen did not cause a significant rise in TNF alpha levels. These results indicate that TNF alpha may be useful for the diagnosis of aGVHD and for differentiating between aGVHD and other BMT-related complications, such as infection.

语种: 英语
WOS记录号: WOS:000170000400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55430
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Beijing Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Huang, XJ,Wan, J,Lu, DP. Serum TNF alpha levels in patients with acute graft-versus-host disease after bone marrow transplantation[J]. LEUKEMIA,2001,15(7):1089-1091.
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