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学科主题临床医学
Serum TNF alpha levels in patients with acute graft-versus-host disease after bone marrow transplantation
Huang, XJ; Wan, J; Lu, DP
关键词Acute Graft-versus-host Disease (Agvhd) Tnf Alpha Bone Marrow Transplantation Infection
刊名LEUKEMIA
2001-07-01
15期:7页:1089-1091
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
英文摘要

Tumor necrosis factor alpha (TNF alpha) has been implicated in the pathogenesis of graft-versus-host disease (GVHD). In this study, serum levels of TNF alpha were assessed by ELISA in 243 sera samples from 40 patients who had undergone allogeneic bone marrow transplantation (BMT). Serum TNF alpha levels were measured before BMT and at different time points after BMT. The results were correlated with acute GVHD (aGVHD), infection and conditioning regimen. Serum TNF alpha levels were significantly higher in patients with grades II-IV aGVHD than in those with grade 0 or I aGVHD, but there was no clear correlation between serum TNF alpha and severity of aGVHD. Serum TNF alpha levels in infected patients were not statistically different from those in patients without infection. The conditioning regimen did not cause a significant rise in TNF alpha levels. These results indicate that TNF alpha may be useful for the diagnosis of aGVHD and for differentiating between aGVHD and other BMT-related complications, such as infection.

语种英语
WOS记录号WOS:000170000400012
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55430
专题北京大学第二临床医学院_血液科
作者单位Beijing Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Huang, XJ,Wan, J,Lu, DP. Serum TNF alpha levels in patients with acute graft-versus-host disease after bone marrow transplantation[J]. LEUKEMIA,2001,15(7):1089-1091.
APA Huang, XJ,Wan, J,&Lu, DP.(2001).Serum TNF alpha levels in patients with acute graft-versus-host disease after bone marrow transplantation.LEUKEMIA,15(7),1089-1091.
MLA Huang, XJ,et al."Serum TNF alpha levels in patients with acute graft-versus-host disease after bone marrow transplantation".LEUKEMIA 15.7(2001):1089-1091.
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