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学科主题临床医学
Expression of connective tissue growth factor is in agreement with the expression of VEGF, VEGF-C, -D and associated with shorter survival in gastric cancer
Liu, Luying; Li, Zhongwu; Feng, Guoshuang; You, Weicheng; Li, Jiyou
关键词Connective Tissue Growth Factor Gastric Cancer Lymph Node Metastasis Prognosis Vascular Endothelial Growth Factor Vegf-c Vegf-d
刊名PATHOLOGY INTERNATIONAL
2007-11-01
DOI10.1111/j.1440-1827.2007.02162.x
57期:11页:712-718
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]INDEPENDENT PROGNOSTIC MARKER ; VASCULAR ENDOTHELIAL-CELLS ; ANGIOGENESIS IN-VIVO ; TUMOR PROGRESSION ; FACTOR RECEPTORS ; CCN FAMILY ; METASTASIS ; LYMPHANGIOGENESIS ; ADENOCARCINOMA ; REGULATORS
英文摘要

Connective tissue growth factor (CTGF) is believed to be a multifunctional signaling modulator involved in a wide variety of biological or pathological processes including carcinogenesis. The role of CTGF in gastric cancer (GC) has not been reported so far. In the present study the expression of CTGF, vascular endothelial growth factor (VEGF), VEGF-C and VEGF-D on immunohistochemistry in GC and the correlation between the expression of CTGF and VEGF, VEGF-C, VEGF-D were examined, along with the correlation between the expression of CTGF and clinicopathological parameters, as well as survival of the patients with GC. The expression of CTGF was significantly in agreement with expression of VEGF, VEGF-C and VEGF-D (kappa and P, respectively: 0.538, P < 0.001; 0.502, P < 0.001; 0.558, P < 0.001). High CTGF expression was significantly associated with lymph nodes metastasis (P = 0.038) and lower postoperative 5 year overall survival rates (23.9%) compared with those patients with low CTGF expression (48.4%, P = 0.0035). The present findings suggest that CTGF is a useful prognostic marker for GC. High CTGF expression is associated with the risk of lymph nodes metastasis and a poor survival time in GC.

语种英语
WOS记录号WOS:000249994600002
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55432
专题北京大学临床肿瘤学院_病理科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Pathol, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Canc Epidemiol, Beijing 100036, Peoples R China
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Liu, Luying,Li, Zhongwu,Feng, Guoshuang,et al. Expression of connective tissue growth factor is in agreement with the expression of VEGF, VEGF-C, -D and associated with shorter survival in gastric cancer[J]. PATHOLOGY INTERNATIONAL,2007,57(11):712-718.
APA Liu, Luying,Li, Zhongwu,Feng, Guoshuang,You, Weicheng,&Li, Jiyou.(2007).Expression of connective tissue growth factor is in agreement with the expression of VEGF, VEGF-C, -D and associated with shorter survival in gastric cancer.PATHOLOGY INTERNATIONAL,57(11),712-718.
MLA Liu, Luying,et al."Expression of connective tissue growth factor is in agreement with the expression of VEGF, VEGF-C, -D and associated with shorter survival in gastric cancer".PATHOLOGY INTERNATIONAL 57.11(2007):712-718.
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