北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 病理科  > 期刊论文
学科主题: 临床医学
题名:
Expression of connective tissue growth factor is in agreement with the expression of VEGF, VEGF-C, -D and associated with shorter survival in gastric cancer
作者: Liu, Luying; Li, Zhongwu; Feng, Guoshuang; You, Weicheng; Li, Jiyou
关键词: connective tissue growth factor ; gastric cancer ; lymph node metastasis ; prognosis ; vascular endothelial growth factor ; VEGF-C ; VEGF-D
刊名: PATHOLOGY INTERNATIONAL
发表日期: 2007-11-01
DOI: 10.1111/j.1440-1827.2007.02162.x
卷: 57, 期:11, 页:712-718
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: INDEPENDENT PROGNOSTIC MARKER ; VASCULAR ENDOTHELIAL-CELLS ; ANGIOGENESIS IN-VIVO ; TUMOR PROGRESSION ; FACTOR RECEPTORS ; CCN FAMILY ; METASTASIS ; LYMPHANGIOGENESIS ; ADENOCARCINOMA ; REGULATORS
英文摘要:

Connective tissue growth factor (CTGF) is believed to be a multifunctional signaling modulator involved in a wide variety of biological or pathological processes including carcinogenesis. The role of CTGF in gastric cancer (GC) has not been reported so far. In the present study the expression of CTGF, vascular endothelial growth factor (VEGF), VEGF-C and VEGF-D on immunohistochemistry in GC and the correlation between the expression of CTGF and VEGF, VEGF-C, VEGF-D were examined, along with the correlation between the expression of CTGF and clinicopathological parameters, as well as survival of the patients with GC. The expression of CTGF was significantly in agreement with expression of VEGF, VEGF-C and VEGF-D (kappa and P, respectively: 0.538, P < 0.001; 0.502, P < 0.001; 0.558, P < 0.001). High CTGF expression was significantly associated with lymph nodes metastasis (P = 0.038) and lower postoperative 5 year overall survival rates (23.9%) compared with those patients with low CTGF expression (48.4%, P = 0.0035). The present findings suggest that CTGF is a useful prognostic marker for GC. High CTGF expression is associated with the risk of lymph nodes metastasis and a poor survival time in GC.

语种: 英语
WOS记录号: WOS:000249994600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55432
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Pathol, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Canc Epidemiol, Beijing 100036, Peoples R China

Recommended Citation:
Liu, Luying,Li, Zhongwu,Feng, Guoshuang,et al. Expression of connective tissue growth factor is in agreement with the expression of VEGF, VEGF-C, -D and associated with shorter survival in gastric cancer[J]. PATHOLOGY INTERNATIONAL,2007,57(11):712-718.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Luying]'s Articles
[Li, Zhongwu]'s Articles
[Feng, Guoshuang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Luying]‘s Articles
[Li, Zhongwu]‘s Articles
[Feng, Guoshuang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace