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学科主题: 临床医学
题名:
Diabetes, prediabetes and cancer mortality
作者: Zhou, X. H.1,2,3; Qiao, Q.1,4; Zethelius, B.5; Pyorala, K.6; Soderberg, S.7,8,9; Pajak, A.10; Stehouwer, C. D. A.11,12; Heine, R. J.13,14; Jousilahti, P.4; Ruotolo, G.15,16; Nilsson, P. M.17; Calori, G.15; Tuomilehto, J.1,4,18; DECODE Study Grp
关键词: Cancer ; Diabetes ; Mortality
刊名: DIABETOLOGIA
发表日期: 2010-09-01
DOI: 10.1007/s00125-010-1796-7
卷: 53, 期:9, 页:1867-1876
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: IMPAIRED GLUCOSE-TOLERANCE ; 12-YEAR FOLLOW-UP ; DIAGNOSTIC-CRITERIA ; BLADDER-CANCER ; PLASMA-GLUCOSE ; UNITED-STATES ; BREAST-CANCER ; RISK-FACTORS ; MELLITUS ; INSULIN
英文摘要:

Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT.

Methods Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed for 5.9 to 36.8 years. Cox proportional hazards analysis with adjustment for cohort, age, BMI, total cholesterol, blood pressure and smoking status was used to estimate HRs for cancer mortality.

Results Compared with people in the normal glucose category, multivariable adjusted HRs (95% CI) for cancer mortality were 1.13 (1.00, 1.28), 1.27 (1.02, 1.57) and 1.71 (1.35, 2.17) in men with prediabetes, previously undiagnosed diabetes and known diabetes, respectively; in women they were 1.11 (0.94, 1.30), 1.31 (1.00, 1.70) and 1.43 (1.01, 2.02), respectively. Significant increases in deaths from cancer of the stomach, colon-rectum and liver in men with prediabetes and diabetes, and deaths from cancers of the liver and pancreas in women with diabetes were also observed. In individuals without known diabetes, the HR (95% CI) for cancer mortality corresponding to a one standard deviation increase in fasting plasma glucose was 1.06 (1.02, 1.09) and in 2 h plasma glucose was 1.07 (1.03, 1.11).

Conclusions/interpretation Diabetes and prediabetes were associated with an increased risk of cancer death, particularly death from liver cancer. Mortality from all cancers rose linearly with increasing glucose concentrations.

语种: 英语
所属项目编号: 118492
项目资助者: Academy of Finland
WOS记录号: WOS:000281012200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55433
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
2.Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, Beijing 100871, Peoples R China
3.Peking Univ, Ctr Diabet, Beijing 100871, Peoples R China
4.Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
5.Univ Uppsala Hosp, Dept Publ Hlth Geriatr, Uppsala, Sweden
6.Univ Eastern Finland, Inst Clin Med, Kuopio, Finland
7.Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden
8.Umea Univ Hosp, Ctr Heart, S-90185 Umea, Sweden
9.Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
10.Eli Lilly & Co, Indianapolis, IN 46285 USA
11.AstraZeneca R&D, Molndal, Sweden
12.Lund Univ, Univ Hosp, Dept Clin Sci, Malmo, Sweden
13.S Ostrobothnia Cent Hosp, Seinajoki, Finland
14.Jagiellonian Univ, Dept Epidemiol & Populat Studies, Coll Med, Inst Publ Hlth,Fac Hlth Sci, Krakow, Poland
15.Maastricht Univ, Med Ctr, Dept Internal Med, Az Maastricht, Netherlands
16.Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht CARIM, Az Maastricht, Netherlands
17.Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands
18.Ist Sci San Raffaele, Div Metab & Cardiovasc Dis, I-20132 Milan, Italy

Recommended Citation:
Zhou, X. H.,Qiao, Q.,Zethelius, B.,et al. Diabetes, prediabetes and cancer mortality[J]. DIABETOLOGIA,2010,53(9):1867-1876.
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