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学科主题: 临床医学
题名:
Anti-Inflammatory Effect of Qingpeng Ointment in Atopic Dermatitis-Like Murine Model
作者: Li, Yun-Zhu; Lu, Xue-Yan; Jiang, Wei; Li, Lin-Feng
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2013
DOI: 10.1155/2013/907016
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: NC/NGA MICE ; ALLERGIC DERMATITIS ; STRATUM-CORNEUM ; ANIMAL-MODELS ; SKIN-LESIONS ; MAST-CELLS ; EXPRESSION ; BARRIER ; IL-17 ; HYPERPRODUCTION
英文摘要:

Qingpeng ointment (QP) is a Chinese medicine which has been used in treatment of atopic dermatitis (AD) in China. AD-like lesions were induced in BALB/c mice by repeated application of 2,4-dinitrofluorobenzene (DNFB) on shaved backs. The mice were then treated for 2 weeks with QP of different concentrations and Mometasone Furoate cream (MF), respectively. Macroscopic and microscopic changes of the skin lesions were observed after the treatment. The levels of serum immunoglobulin (Ig) E, tissue interferon (IFN)-gamma, and interleukin (IL)-4 and IL-17A and the levels of involucrin, filaggrin, and kallikrein7 in epidermis were measured. The results show severe dermatitis with immune profiles similar to human acute AD. A significant infiltration of CD4(+) T and mast cells was observed in dermis of lesion but inhibited by QP after a 2-week treatment with it. The production of IgE, IL-4 and the mRNA expression of IL-17A were also suppressed, but the level of IFN-gamma was increased. MF suppressed all production of these cytokines and IgE. Accordingly, the mechanism of QP on AD might correlate with its ability of modulating the immune dysfunctions rather than suppressing them. It had no effect on expressions of involucrin and filaggrin, except that its vehicle decreased the level of kallikrein7.

语种: 英语
项目资助者: Chinese Association of the Integration of Traditional and Western Medicine
WOS记录号: WOS:000323962500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55437
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: Peking Univ Third Hosp, Dept Dermatol, Beijing 100191, Peoples R China

Recommended Citation:
Li, Yun-Zhu,Lu, Xue-Yan,Jiang, Wei,et al. Anti-Inflammatory Effect of Qingpeng Ointment in Atopic Dermatitis-Like Murine Model[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
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