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学科主题: 公共卫生
题名:
Corn oligopeptides protect against early alcoholic liver injury in rats
作者: Zhang, Feng; Zhang, Jiali; Li, Yong1
关键词: Corn oligopeptides ; Alcoholic liver injury ; Antioxidation ; Lipid metabolism
刊名: FOOD AND CHEMICAL TOXICOLOGY
发表日期: 2012-06-01
DOI: 10.1016/j.fct.2012.03.083
卷: 50, 期:6, 页:2149-2154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology ; Toxicology
研究领域[WOS]: Food Science & Technology ; Toxicology
关键词[WOS]: BLOOD-LIPIDS ; DISEASE ; PEPTIDES ; MICE ; METABOLISM ; MECHANISMS ; PRODUCTS
英文摘要:

Background: The present study aimed to investigate the effects of corn oligopeptides (COPs) on early alcoholic liver injury in rats. A total of 70 Wistar rats were randomly assigned to 7 groups, including a normal control group, 3 alcohol control groups (2.0, 4.0 and 6.0 g/kg/BW ethanol), and 3 COP intervention groups (2.0, 4.0 and 6.0 g/kg/BW ethanol, with 900 mg/kg/BW COPs). The study duration lasted for 4 weeks. Serum markers were assayed, and a histopathological examination was conducted.

Results: We found that the COP treatment prevented the elevation of serum aminotransferase and alleviated the hepatic histological damage that was induced by alcohol. In addition, the COPs counteracted the changes in the SOD activity and the MDA content in serum. Furthermore, the COPs ameliorated the abnormal lipid metabolism.

Conclusion: These findings suggest that COPs have a significant protective effect on early alcoholic liver injury in rats. (C) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: Foundation from the Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000305719700047
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55441
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Feng,Zhang, Jiali,Li, Yong. Corn oligopeptides protect against early alcoholic liver injury in rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2012,50(6):2149-2154.
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