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Research on the relationship between brain anoxia at different regional oxygen saturations and brain damage using near-infrared spectroscopy
Hou, Xinlin; Ding, Haiyan; Teng, Yichao; Zhou, Congle; Tang, Xiuying; Li, Shuangshuang; Ding, Haishu
关键词Near-infrared Spectroscopy Hypoxia Brain Damage Pig
刊名PHYSIOLOGICAL MEASUREMENT
2007-10-01
DOI10.1088/0967-3334/28/10/010
28期:10页:1251-1265
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Engineering, Biomedical ; Physiology
研究领域[WOS]Biophysics ; Engineering ; Physiology
关键词[WOS]CEREBRAL OXYGENATION ; ENCEPHALOPATHY ; INFANTS
英文摘要

The objective of this paper is to investigate the difference in physiological parameters, EEG and morphology of brain tissues in newborn pigs with different regional oxygen saturations of brain (rSO(2)) and provide a basis for the determination of brain injury and degree of injury with the rSO(2) in clinical practice. A noninvasive near-infrared spectroscopy (NIRS) technique was used to monitor the rSO2 of 27 newborn pigs. After mechanical ventilation and inhalation of 3-11% oxygen for 30 min by the newborn pigs, the pigs were grouped according to the rSO(2) in the brain caused by inhalation of different concentrations of oxygen. There were six animals each in rSO(2) < 30%, 30-35%, 35-40%, 40-50% groups and three animals in the rSO(2) > 60% group (normal control). The physiological parameters and the EEG were monitored during the experiment. The animals were sacrificed by decollation at 72 hours after brain injury, and light microscope examination and pathological analysis of the ultrastructure were conducted on the brain tissues in the CA1 zone of hippocampi. In rSO(2) > 40% groups, the mean arterial pressure (MAP) was stable and there were no significant changes in blood lactic acid, amplitudes of the EEG, light microscopic findings and ultrastructure after hypoxia. When the rSO(2) was between 30% and 40%, the MAP was stable, the level of blood lactic acid increased, metabolic acidosis occurred, there was no significant change in the amplitudes of the EEG, there were ischemic changes in brain tissues under a light microscope and there was an injury of mitochondria in the neurons in the CA1 zone of hippocampi. When the rSO(2) was less than 30%, circulatory failure occurred, the level of blood lactic acid increased, there was serious metabolic acidosis, the amplitudes of the EEG significantly decreased, there were vacuolization and broken fragments of cells under the light microscope and the mitochondria in the neurons in the CA1 zone of hippocampi were seriously injured. Under varying degrees of hypoxia, when the rSO(2) is between 30% and 40%, brain injury occurs and the functional zones of mitochondria are injured in newborn pigs. When the rSO(2) is less than 30%, the brain functions are seriously abnormal, and the serious morphological impairment in the functional zones of mitochondria is the basis for the disturbance of energy metabolism in brain neurocytes after hypoxia and the sequelae of the nervous system.

语种英语
WOS记录号WOS:000249981600010
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55446
专题北京大学第一临床医学院_儿科
作者单位1.Tsing Hua Univ, Dept Biomed Engn, Sch Med, Beijing 100084, Peoples R China
2.Beijing Univ, First Hosp, Dept Pediat, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Hou, Xinlin,Ding, Haiyan,Teng, Yichao,et al. Research on the relationship between brain anoxia at different regional oxygen saturations and brain damage using near-infrared spectroscopy[J]. PHYSIOLOGICAL MEASUREMENT,2007,28(10):1251-1265.
APA Hou, Xinlin.,Ding, Haiyan.,Teng, Yichao.,Zhou, Congle.,Tang, Xiuying.,...&Ding, Haishu.(2007).Research on the relationship between brain anoxia at different regional oxygen saturations and brain damage using near-infrared spectroscopy.PHYSIOLOGICAL MEASUREMENT,28(10),1251-1265.
MLA Hou, Xinlin,et al."Research on the relationship between brain anoxia at different regional oxygen saturations and brain damage using near-infrared spectroscopy".PHYSIOLOGICAL MEASUREMENT 28.10(2007):1251-1265.
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