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学科主题: 临床医学
题名:
Review article: Drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis
作者: Gao, Ying1,2; Zhao, Ming-Hui1
关键词: anti-neutrophil cytoplasmic antibodies (ANCA) ; drug-induced ; vasculitis
刊名: NEPHROLOGY
发表日期: 2009-02-01
DOI: 10.1111/j.1440-1797.2009.01100.x
卷: 14, 期:1, 页:33-41
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ANCA-POSITIVE VASCULITIS ; CHURG-STRAUSS-SYNDROME ; OF-THE-LITERATURE ; PROPYLTHIOURACIL-INDUCED VASCULITIS ; SENSORINEURAL HEARING-LOSS ; MINOCYCLINE-INDUCED LUPUS ; ANTIMYELOPEROXIDASE ANTIBODIES ; GRAVES-DISEASE ; MPO-ANCA ; ANTITHYROID DRUGS
英文摘要:

A recent development in the field of vasculitis is the increasing recognition that certain medications such as propylthiouracil can induce anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). This review focuses on the data on causal drugs, possible pathogenesis, clinical description, diagnosis, treatment and prognosis of patients with drug-induced AAV. The pathogenesis of drug-induced AAV might be multifactorial. The clinical manifestations are similar to those of primary AAV, but ANCA with multi-antigenicity may help to differentiate it from primary AAV. The diagnosis of drug-induced AAV is based on the temporal relationship between clinically evident vasculitis and administration of the offending drugs, and excluding medical conditions that mimic vasculitis and other definable types of vasculitis. After the diagnosis of drug-induced AAV was made, the offending drugs should be withdrawn immediately, and appropriate immunosuppressive therapy should be administered only for patients with vital organ involvement. The duration of immunosuppressive therapy should be much shorter than that in primary AAV and long-term maintenance therapy might not be necessary. The prognosis of patients with drug-induced AAV is good as long as the offending drug is discontinued in time.

语种: 英语
所属项目编号: 30725034 ; 30500459
项目资助者: National Natural Science Fund for Distinguished Young Scholars ; National Natural Science Fund
WOS记录号: WOS:000264552700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55459
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Dept Nephrol, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Endocrinol, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Gao, Ying,Zhao, Ming-Hui. Review article: Drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis[J]. NEPHROLOGY,2009,14(1):33-41.
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