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Review article: Drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis
Gao, Ying1,2; Zhao, Ming-Hui1
关键词Anti-neutrophil Cytoplasmic Antibodies (Anca) Drug-induced Vasculitis
刊名NEPHROLOGY
2009-02-01
DOI10.1111/j.1440-1797.2009.01100.x
14期:1页:33-41
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]ANCA-POSITIVE VASCULITIS ; CHURG-STRAUSS-SYNDROME ; OF-THE-LITERATURE ; PROPYLTHIOURACIL-INDUCED VASCULITIS ; SENSORINEURAL HEARING-LOSS ; MINOCYCLINE-INDUCED LUPUS ; ANTIMYELOPEROXIDASE ANTIBODIES ; GRAVES-DISEASE ; MPO-ANCA ; ANTITHYROID DRUGS
英文摘要

A recent development in the field of vasculitis is the increasing recognition that certain medications such as propylthiouracil can induce anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). This review focuses on the data on causal drugs, possible pathogenesis, clinical description, diagnosis, treatment and prognosis of patients with drug-induced AAV. The pathogenesis of drug-induced AAV might be multifactorial. The clinical manifestations are similar to those of primary AAV, but ANCA with multi-antigenicity may help to differentiate it from primary AAV. The diagnosis of drug-induced AAV is based on the temporal relationship between clinically evident vasculitis and administration of the offending drugs, and excluding medical conditions that mimic vasculitis and other definable types of vasculitis. After the diagnosis of drug-induced AAV was made, the offending drugs should be withdrawn immediately, and appropriate immunosuppressive therapy should be administered only for patients with vital organ involvement. The duration of immunosuppressive therapy should be much shorter than that in primary AAV and long-term maintenance therapy might not be necessary. The prognosis of patients with drug-induced AAV is good as long as the offending drug is discontinued in time.

语种英语
WOS记录号WOS:000264552700006
项目编号30725034 ; 30500459
资助机构National Natural Science Fund for Distinguished Young Scholars ; National Natural Science Fund
引用统计
被引频次:60[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55459
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Dept Nephrol, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Endocrinol, Hosp 1, Beijing 100871, Peoples R China
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GB/T 7714
Gao, Ying,Zhao, Ming-Hui. Review article: Drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis[J]. NEPHROLOGY,2009,14(1):33-41.
APA Gao, Ying,&Zhao, Ming-Hui.(2009).Review article: Drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis.NEPHROLOGY,14(1),33-41.
MLA Gao, Ying,et al."Review article: Drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis".NEPHROLOGY 14.1(2009):33-41.
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