北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Cocaine-induced Impulsive Choices Are Accompanied by Impaired Delay-dependent Anticipatory Activity in Basolateral Amygdala
作者: Zuo, Yanfang; Wang, Xinsheng; Cui, Cailian1; Luo, Fei2; Yu, Peng; Wang, XueWei
刊名: JOURNAL OF COGNITIVE NEUROSCIENCE
发表日期: 2012
卷: 24, 期:1, 页:196-211
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology ; Social Sciences
类目[WOS]: Neurosciences ; Psychology, Experimental
研究领域[WOS]: Neurosciences & Neurology ; Psychology
关键词[WOS]: HIGHER DISCOUNT RATES ; ORBITOFRONTAL CORTEX ; DOPAMINE NEURONS ; PRIMATE AMYGDALA ; DECISION-MAKING ; HUMAN BRAIN ; REWARD ; EXPOSURE ; HEROIN ; DRUG
英文摘要:

Addicts and drug-experienced animals have decision-making deficits in delayed reinforcement choice task, in which they prefer small immediate rewards over large delayed rewards. Here, we show evidence that this deficit is accompanied by changed coding of delay length in the basolateral amygdala (BLA). A subset of neurons in BLA demonstrated delay-dependent anticipatory activity (either increase or decrease as a function of delay to reward) in naive rats. After 30 days of withdrawal from chronic cocaine treatment (30 mg/kg/day for 10 days ip), the proportion of delay-dependent anticipatory neurons reduced, whereas delay-dependent activity in response to elapsed delay after reward delivery increased, both in the proportion of delay-dependent neurons and in the extent of delay dependence. Cocaine exposure increased, instead of decreased, BLA neuronal expectation for different reward magnitudes. These results indicate that BLA is critical for representing and maintaining the information of delayed reward before its delivery, and cocaine exposure may affect decision-making by impairing perception of delay instead of the ability to assess the differences in reward size.

语种: 英语
所属项目编号: 30770690 ; 2009CB522003
项目资助者: National Natural Science Foundation ; National Basic Research Program of China
WOS记录号: WOS:000297324600016
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55461
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Cocaine-induced Impulsive Choices Are Accompanied by Impaired Delay-dependent Anticipatory Activity in Basolateral Amygdala.pdf(872KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Chinese Acad Sci, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Beijing 100191, Peoples R China

Recommended Citation:
Zuo, Yanfang,Wang, Xinsheng,Cui, Cailian,et al. Cocaine-induced Impulsive Choices Are Accompanied by Impaired Delay-dependent Anticipatory Activity in Basolateral Amygdala[J]. JOURNAL OF COGNITIVE NEUROSCIENCE,2012,24(1):196-211.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zuo, Yanfang]'s Articles
[Wang, Xinsheng]'s Articles
[Cui, Cailian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zuo, Yanfang]‘s Articles
[Wang, Xinsheng]‘s Articles
[Cui, Cailian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace