北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Sulfur dioxide inhibits excessively activated endoplasmic reticulum stress in rats with myocardial injury
作者: Chen, Shanshan1; Du, Junbao1,2; Liang, Yinfang1; Ochs, Todd3; Liu, Die1; Zhu, Lulu1; Tang, Xiuying4; Tang, Chaoshu2,5; Jin, Hongfang1
关键词: Sulfur dioxide ; Isoproterenol ; Myocardial injury ; Endoplasmic reticulum stress
刊名: HEART AND VESSELS
发表日期: 2012-09-01
DOI: 10.1007/s00380-011-0192-7
卷: 27, 期:5, 页:505-516
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: UNFOLDED PROTEIN RESPONSE ; AIR-POLLUTION ; SERUM SULFITE ; ISOPROTERENOL ; HEART ; DYSFUNCTION ; METABOLISM ; INFARCTION ; APOPTOSIS ; NECROSIS
英文摘要:

It has been demonstrated that excessively activated endoplasmic reticulum stress (ERS) is related to myocardial injury. The study was designed to explore the possible role of sulfur dioxide (SO2) in protecting excessively activated ERS in rats with isoproterenol (ISO)-induced myocardial injury. Wistar rats were randomly divided into control, ISO, and ISO + SO2 groups. Cardiac catheterization-derived hemodynamic parameters and myocardial enzymes in plasma were measured. Microstructure changes in myocardial tissues were examined. Cardiomyocyte apoptosis was detected by TUNEL method. Myocardial SO2 content and aspartate amino transferase (AAT) activity were detected. Meanwhile, protein and mRNA expressions of myocardial AAT1, AAT2, and ERS markers (GRP78, caspase-12, and CHOP) were evaluated. The results showed that cardiac function was decreased, myocardial microstructure was damaged, and myocardial enzyme levels and cardiomyocyte apoptosis were increased with a downregulated endogenous AAT/SO2 pathway, and that ERS markers were upregulated at transcriptional and translational levels in ISO-treated rats. However, the administration of an SO2 donor, resulting in an increased SO2 content in myocardial tissues, improved cardiac function and myocardial structure, and ameliorated myocardial enzyme levels and cardiomyocyte apoptosis associated with a downregulation of excessively activated ERS. In conclusion, the endogenous AAT/SO2 pathway was probably responsible for the inhibition of excessively activated ERS, which might be involved in the mechanism of ISO-induced myocardial injury.

语种: 英语
所属项目编号: 20070001702 ; 20070001770 ; 81070111 ; 30821001 ; 30801251 ; 2011CB503904 ; 7093136
项目资助者: Ministry of Education of China ; National Natural Science Foundation of China ; Major State Basic Research Development Program ; Natural Science Foundation of Beijing
WOS记录号: WOS:000308817200011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55462
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Northwestern Univ, Chicago, IL 60611 USA
2.Minist Educ, Key Lab Mol Cardiol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Electron Microscope, Ctr Lab, Beijing 100034, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Shanshan,Du, Junbao,Liang, Yinfang,et al. Sulfur dioxide inhibits excessively activated endoplasmic reticulum stress in rats with myocardial injury[J]. HEART AND VESSELS,2012,27(5):505-516.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, Shanshan]'s Articles
[Du, Junbao]'s Articles
[Liang, Yinfang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, Shanshan]‘s Articles
[Du, Junbao]‘s Articles
[Liang, Yinfang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace