|alpha-Adrenoceptor agonists for the treatment of vasovagal syncope: a meta-analysis of worldwide published data|
|Liao, Ying1; Li, Xueying2; Zhang, Yanwu3; Chen, Stella4; Tang, Chaoshu5; Du, Junbao1,6|
|关键词||Alpha-adrenoceptor Agonists Meta-analysis Randomized Controlled Trial Vasovagal Syncope|
|WOS标题词||Science & Technology|
|关键词[WOS]||NEURALLY-MEDIATED SYNCOPE ; PLACEBO-CONTROLLED TRIAL ; HEAD-UP TILT ; DOUBLE-BLIND ; NEUROCARDIOGENIC SYNCOPE ; CLINICAL-TRIALS ; MIDODRINE ; MANAGEMENT ; ETILEFRINE ; CAPACITANCE|
The present study was aimed at evaluating present randomized controlled trials (RCTs) regarding the effect of alpha-adrenoceptor agonists on vasovagal syncope (VVS).
According to inclusion and exclusion criteria, articles were selected from medical electronic databases. RCTs were then assessed based on the Juni assessment, and meta-analysis was completed using the Review Manager 4.2 software. Indication to further evaluate effects was the recurrence of syncope during follow-up treatment or a response in the head-up tilt test (HUT) after treatment. The results were stated as odd ratio (OR), with a 95% confidence interval (CI) and a p < 0.05 significant level.
In total, six RCTs were selected. Funnel plot analysis showed possible publication bias. Meta-analysis of the six RCTs, including all 165 patients in the treatment group and 164 patients in the control group, indicated that alpha-adrenoceptor agonists were more effective than placebos in treating VVS (OR = 0.21, 95% CI: 0.06-0.77, p = 0.02). The further, weighted independent t-test disclosed that the weighted mean percentage of responders for midodrine (76.3% +/- 7.7%) was significantly higher than that for etilefrine (65.5% +/- 15.4%) (t = 5.863, p < 0.001).
The currently published RCTs support that alpha-adrenoceptor agonists might be effective for VVS. Midodrine can be regarded as a better choice compared with etilefrine.
|项目编号||2004BA720A10 ; 2006 CB503807 ; 30821001 ; 2007-2003|
|资助机构||National Tenth Five-Year Plan Research Project of China ; Changjiang Scholar Program and the Major Basic Research Project of China ; National Natural Science Foundation of China ; Capital Medical Development Fundation|
|作者单位||1.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China|
2.Peking Univ, Dept Stat, Hosp 1, Beijing 100034, Peoples R China
3.Peking Univ, Med Lib, Hosp 1, Beijing 100034, Peoples R China
4.Torrey Pines High Sch, San Diego, CA USA
5.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
6.Minist Educ China, Key Lab Mol Cardiol, Beijing, Peoples R China
|Liao, Ying,Li, Xueying,Zhang, Yanwu,et al. alpha-Adrenoceptor agonists for the treatment of vasovagal syncope: a meta-analysis of worldwide published data[J]. ACTA PAEDIATRICA,2009,98(7):1194-1200.|
|APA||Liao, Ying,Li, Xueying,Zhang, Yanwu,Chen, Stella,Tang, Chaoshu,&Du, Junbao.(2009).alpha-Adrenoceptor agonists for the treatment of vasovagal syncope: a meta-analysis of worldwide published data.ACTA PAEDIATRICA,98(7),1194-1200.|
|MLA||Liao, Ying,et al."alpha-Adrenoceptor agonists for the treatment of vasovagal syncope: a meta-analysis of worldwide published data".ACTA PAEDIATRICA 98.7(2009):1194-1200.|
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