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A study on homocysteine-specific CTL from patients with ankylosing spondylitis and reactive arthritis
Gao, XM; Chilvers, MM; Wordsworth, P
会议文集10TH INTERNATIONAL CONGRESS ON IMMUNOLOGY, VOLS 1 AND 2 ; 10th International Congress of Immunology ; 10TH INTERNATIONAL CONGRESS ON IMMUNOLOGY, VOLS 1 AND 2 ; 10th International Congress of Immunology
会议文集10TH INTERNATIONAL CONGRESS ON IMMUNOLOGY, VOLS 1 AND 2 ; 10th International Congress of Immunology ; 10TH INTERNATIONAL CONGRESS ON IMMUNOLOGY, VOLS 1 AND 2 ; 10th International Congress of Immunology
会议日期NOV 01-06, 1998
1998
会议地点NEW DELHI, INDIA
关键词Immunology
通讯作者Gao, XM (reprint author), Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China.
出版者MEDIMOND S R L
出版地40128 BOLOGNA
收录类别CPCI-S
ISBN88-323-1101-1
摘要Homocysteine is one of the major thiols in human plasma and exists in both protein-bound and free thiol forms. It has been shown that homocysteine can modify, through disulfide bonding, class I HLA antigens in the endoplasmic reticulum of the cell. We have also identified CTL, in patients with ankylosing spondylitis or reactive arthritis. that recognised homocysteine-modified HLA B27. A68 and B8. TCR usage by these T cells was analysed by determining the cDNA sequences encoding their TCR alpha- and beta-chains. TCRAV4 and TCRBV23 gene segments were strongly favoured by HLA A68-restricted Hom-CTL from two unrelated patients. The TCR of B37-restricted CTL appeared to be relatively more heterogeneous. although one of the B27-restricted T cell clones employed TCR V gene segments (AV20S1 and BV5S1) very similar to that of the A68-restricted CTL. An arginine or lysine residue at position alpha 93 of the alpha-chain frequently appeared in the TCR of A68- and B8-restricted Hom-CTL, which may suggest a. potential salt-bridge between the carboxyl group of homocysteine and TCR.
语种英语
文献类型会议论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/5546
专题北京大学基础医学院_免疫学系
作者单位Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Gao, XM,Chilvers, MM,Wordsworth, P. A study on homocysteine-specific CTL from patients with ankylosing spondylitis and reactive arthritis[C]. 40128 BOLOGNA:MEDIMOND S R L,1998.
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