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学科主题: 基础医学
题名:
8,9-Epoxyeicosatrienoic Acid Inhibits Antibody Production of B Lymphocytes in Mice
作者: Gao, Yanxiang1; Feng, Juan1; Ma, Kongyang1; Zhou, Zhou1; Zhu, Yi1; Xu, Qingbo2; Wang, Xian1
刊名: PLOS ONE
发表日期: 2012-07-03
DOI: 10.1371/journal.pone.0040258
卷: 7, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SOLUBLE EPOXIDE HYDROLASE ; EPOXYGENASE-DERIVED EICOSANOIDS ; PLASMA-CELL DIFFERENTIATION ; EPOXYEICOSATRIENOIC ACIDS ; ARACHIDONIC-ACID ; HYPERPOLARIZING FACTORS ; ENDOTHELIAL-CELLS ; PROSTAGLANDIN E-2 ; IMMUNE-RESPONSES ; GENE-EXPRESSION
英文摘要:

Epoxyeicosatrienoic acids (EETs), synthesized from arachidonic acid by cytochrome P450 epoxygenases, are converted to dihydroxyeicosatrienoic acids by soluble epoxide hydrolase. EETs exert anti-inflammatory effects. However, the effect of EETs on humoral immunity is poorly understood. The present study is to investigate the potential role of EETs on B cell function and mechanisms. We examined the role of EETs on antibody production of splenic B cells from C57BL/6 and apolipoprotein E-deficient (ApoE-/-) mice by means of ELISA. Of the 4 EET regioisomers, 8,9-EET decreased basal and activation-induced B cell antibody secretion. As well, 8,9-EET significantly inhibited B-cell proliferation and survival, plasma cell differentiation and class-switch recombination. Western blot analysis revealed that lipopolysaccharide-induced nuclear translocation of NF-kappa B could be attenuated by 8,9-EET. Furthermore, germinal center formation was impaired by 8,9-EET in mice in vivo. 8,9-EET may inhibit B-cell function in vitro and in vivo, which suggests a new therapeutic strategy for diseases with excess B cell activation.

语种: 英语
所属项目编号: 2010CB912504 ; 2011CB503904 ; 81121061 ; 81000115 ; 20100001120049 ; B07001
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; Fund of the Chinese Ministry of Education ; Programme of Introducing Talents of Discipline to Universities
WOS记录号: WOS:000306186900032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55471
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Dept Physiol & Pathophysiol,Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Kings Coll London, BHF Ctr, Cardiovasc Div, London WC2R 2LS, England

Recommended Citation:
Gao, Yanxiang,Feng, Juan,Ma, Kongyang,et al. 8,9-Epoxyeicosatrienoic Acid Inhibits Antibody Production of B Lymphocytes in Mice[J]. PLOS ONE,2012,7(7).
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