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学科主题基础医学
8,9-Epoxyeicosatrienoic Acid Inhibits Antibody Production of B Lymphocytes in Mice
Gao, Yanxiang1; Feng, Juan1; Ma, Kongyang1; Zhou, Zhou1; Zhu, Yi1; Xu, Qingbo2; Wang, Xian1
刊名PLOS ONE
2012-07-03
DOI10.1371/journal.pone.0040258
7期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]SOLUBLE EPOXIDE HYDROLASE ; EPOXYGENASE-DERIVED EICOSANOIDS ; PLASMA-CELL DIFFERENTIATION ; EPOXYEICOSATRIENOIC ACIDS ; ARACHIDONIC-ACID ; HYPERPOLARIZING FACTORS ; ENDOTHELIAL-CELLS ; PROSTAGLANDIN E-2 ; IMMUNE-RESPONSES ; GENE-EXPRESSION
英文摘要

Epoxyeicosatrienoic acids (EETs), synthesized from arachidonic acid by cytochrome P450 epoxygenases, are converted to dihydroxyeicosatrienoic acids by soluble epoxide hydrolase. EETs exert anti-inflammatory effects. However, the effect of EETs on humoral immunity is poorly understood. The present study is to investigate the potential role of EETs on B cell function and mechanisms. We examined the role of EETs on antibody production of splenic B cells from C57BL/6 and apolipoprotein E-deficient (ApoE-/-) mice by means of ELISA. Of the 4 EET regioisomers, 8,9-EET decreased basal and activation-induced B cell antibody secretion. As well, 8,9-EET significantly inhibited B-cell proliferation and survival, plasma cell differentiation and class-switch recombination. Western blot analysis revealed that lipopolysaccharide-induced nuclear translocation of NF-kappa B could be attenuated by 8,9-EET. Furthermore, germinal center formation was impaired by 8,9-EET in mice in vivo. 8,9-EET may inhibit B-cell function in vitro and in vivo, which suggests a new therapeutic strategy for diseases with excess B cell activation.

语种英语
WOS记录号WOS:000306186900032
项目编号2010CB912504 ; 2011CB503904 ; 81121061 ; 81000115 ; 20100001120049 ; B07001
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; Fund of the Chinese Ministry of Education ; Programme of Introducing Talents of Discipline to Universities
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55471
专题北京大学基础医学院_心血管所
北京大学基础医学院
作者单位1.Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Dept Physiol & Pathophysiol,Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Kings Coll London, BHF Ctr, Cardiovasc Div, London WC2R 2LS, England
推荐引用方式
GB/T 7714
Gao, Yanxiang,Feng, Juan,Ma, Kongyang,et al. 8,9-Epoxyeicosatrienoic Acid Inhibits Antibody Production of B Lymphocytes in Mice[J]. PLOS ONE,2012,7(7).
APA Gao, Yanxiang.,Feng, Juan.,Ma, Kongyang.,Zhou, Zhou.,Zhu, Yi.,...&Wang, Xian.(2012).8,9-Epoxyeicosatrienoic Acid Inhibits Antibody Production of B Lymphocytes in Mice.PLOS ONE,7(7).
MLA Gao, Yanxiang,et al."8,9-Epoxyeicosatrienoic Acid Inhibits Antibody Production of B Lymphocytes in Mice".PLOS ONE 7.7(2012).
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