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学科主题: 药物依赖
题名:
Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times
作者: Wang, Gui-Bin; Zhang, Xiao-Li; Zhao, Li-Yan; Sun, Li-Li; Wu, Ping; Lu, Lin; Shi, Jie
关键词: Drug-related cues ; Decision making ; Craving ; Heroin addicts ; Different abstinence times
刊名: PSYCHOPHARMACOLOGY
发表日期: 2012-06-01
DOI: 10.1007/s00213-011-2617-5
卷: 221, 期:4, 页:701-708
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: PREFRONTAL CORTEX ; ORBITOFRONTAL CORTEX ; DEPENDENT PATIENTS ; SUBSTANCE USERS ; IMPULSE CONTROL ; RELAPSE ; PREDICTOR ; STRESS ; PERSPECTIVE ; ACTIVATION
英文摘要:

Relapse is a persistent problem in the management of addiction. Drug-related cues are powerful instigators of relapse. Impulsive decision making may contribute to relapse through a poorly considered assessment of the consequences of drug use. Drug cues robustly increase subjective craving, which is frequently associated with relapse.

The present study explored the effects of drug-related cues on decision making and craving in heroin addicts at different abstinence times: 1, 3, 12, and 24 months.

The 75 male participants were given 5 min exposure to neutral and drug-associated cues while decision making performance, craving, blood pressure, heart rate, and emotional state pre- and post-exposure were assessed. The Iowa Gambling Task was used to evaluate decision making ability in heroin addicts.

Drug-related cues exacerbated impulsive decision making and increased craving, heart rate, and systolic pressure in heroin addicts at all abstinence times.

Drug-related cues aggravated decision making and increased craving in former heroin addicts who had been drug-free for 1-24 months, which might have significant clinical implications for the prevention of relapse.

语种: 英语
所属项目编号: 2009CB522000 ; 7092058 ; 81000571 ; 91132719
项目资助者: National Basic Research Program of China ; Natural Science Foundation of Beijing Municipality ; Natural Science Foundation of China
WOS记录号: WOS:000304616300016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55473
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Gui-Bin,Zhang, Xiao-Li,Zhao, Li-Yan,et al. Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times[J]. PSYCHOPHARMACOLOGY,2012,221(4):701-708.
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