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Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times
Wang, Gui-Bin; Zhang, Xiao-Li; Zhao, Li-Yan; Sun, Li-Li; Wu, Ping; Lu, Lin; Shi, Jie
关键词Drug-related Cues Decision Making Craving Heroin Addicts Different Abstinence Times
刊名PSYCHOPHARMACOLOGY
2012-06-01
DOI10.1007/s00213-011-2617-5
221期:4页:701-708
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]PREFRONTAL CORTEX ; ORBITOFRONTAL CORTEX ; DEPENDENT PATIENTS ; SUBSTANCE USERS ; IMPULSE CONTROL ; RELAPSE ; PREDICTOR ; STRESS ; PERSPECTIVE ; ACTIVATION
英文摘要

Relapse is a persistent problem in the management of addiction. Drug-related cues are powerful instigators of relapse. Impulsive decision making may contribute to relapse through a poorly considered assessment of the consequences of drug use. Drug cues robustly increase subjective craving, which is frequently associated with relapse.

The present study explored the effects of drug-related cues on decision making and craving in heroin addicts at different abstinence times: 1, 3, 12, and 24 months.

The 75 male participants were given 5 min exposure to neutral and drug-associated cues while decision making performance, craving, blood pressure, heart rate, and emotional state pre- and post-exposure were assessed. The Iowa Gambling Task was used to evaluate decision making ability in heroin addicts.

Drug-related cues exacerbated impulsive decision making and increased craving, heart rate, and systolic pressure in heroin addicts at all abstinence times.

Drug-related cues aggravated decision making and increased craving in former heroin addicts who had been drug-free for 1-24 months, which might have significant clinical implications for the prevention of relapse.

语种英语
WOS记录号WOS:000304616300016
项目编号2009CB522000 ; 7092058 ; 81000571 ; 91132719
资助机构National Basic Research Program of China ; Natural Science Foundation of Beijing Municipality ; Natural Science Foundation of China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55473
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
北京大学第一临床医学院_口腔科
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Gui-Bin,Zhang, Xiao-Li,Zhao, Li-Yan,et al. Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times[J]. PSYCHOPHARMACOLOGY,2012,221(4):701-708.
APA Wang, Gui-Bin.,Zhang, Xiao-Li.,Zhao, Li-Yan.,Sun, Li-Li.,Wu, Ping.,...&Shi, Jie.(2012).Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times.PSYCHOPHARMACOLOGY,221(4),701-708.
MLA Wang, Gui-Bin,et al."Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times".PSYCHOPHARMACOLOGY 221.4(2012):701-708.
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