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Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol
Xu, Jian-Ping1; Wang, Hong-Xia1; Wang, Wen1; Zhang, Li-Ke1; Tang, Chao-Shu1,2
关键词Ghrelin Metabolism Heart Failure Glucose Lactate Monocarboxylate Transporter-1 Ghs-r
刊名JOURNAL OF PEPTIDE SCIENCE
2010-08-01
DOI10.1002/psc.1253
16期:8页:392-402
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Analytical
资助者State Major Basic Research Development Program of the People&prime ; s Republic of China ; National Natural Science Foundation of China ; State Major Basic Research Development Program of the People&prime ; s Republic of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]DES-OCTANOYL GHRELIN ; ENDOTHELIAL-CELLS ; CARBOHYDRATE-METABOLISM ; GUT HORMONES ; CACHEXIA ; DISEASE ; MORTALITY ; RECEPTOR ; PREVENTS ; PEPTIDE
英文摘要

To explore the effects of ghrelin on disturbed myocardial energy metabolism during chronic heart failure (CHF). Rats were subcutaneously injected with isoproterenol (ISO) for 10 days with or without ghrelin for another 10 days. Enzyme immunoassay was to measure ghrelin concentrations. Compared with the control group, ISO-treated rats showed suppressed cardiac function with high ghrelin/GHS-R expressions. These rats also showed the decreases in food consumption and weight. The decreased levels of plasma glucose and myocardial glucogen, but the high lactate in blood and myocardium showed myocardial metabolic disturbance. Compared with the group given ISO alone, the rats with ghrelin (20 and 100 mu g/kg/day) improved cardiac dysfunction and increased food intake by 13.5 and 14.2% (both P < 0.01), and rate of weight gain by 95% (P < 0.05) and 1.71-fold (P < 0.01), respectively. The plasma glucose were increased by 49.7 and 50.8% (both P < 0.01), and myocardial glucogen, by 40.5 and 51.7% (both P < 0.01), but blood lactate decreased by 1.56- and 1.96-fold (both P < 0.01), and myocardial lactate by 32.1 and 48.7% (both P < 0.05), respectively. Their MCT1 mRNA and protein expressions increased. The myocardial ghrelin/GHS-R pathway can be upregulated during CHF. The ghrelin can attenuate cardiac dysfunction and energy metabolic disturbance in CHF rats. Copyright (C) 2010 European Peptide Society and John Wiley & Sons, Ltd.

语种英语
所属项目编号2006CB503807 ; 30670847
资助者State Major Basic Research Development Program of the People&prime ; s Republic of China ; National Natural Science Foundation of China ; State Major Basic Research Development Program of the People&prime ; s Republic of China ; National Natural Science Foundation of China
WOS记录号WOS:000280462100003
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55474
专题北京大学第一临床医学院_心血管内科
作者单位1.Capital Med Univ, Dept Physiol & Pathophysiol, Beijing 100069, Peoples R China
2.Peking Univ, Inst Cardiovasc Res, Hosp 1, Beijing 100034, Peoples R China
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Xu, Jian-Ping,Wang, Hong-Xia,Wang, Wen,et al. Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol[J]. JOURNAL OF PEPTIDE SCIENCE,2010,16(8):392-402.
APA Xu, Jian-Ping,Wang, Hong-Xia,Wang, Wen,Zhang, Li-Ke,&Tang, Chao-Shu.(2010).Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol.JOURNAL OF PEPTIDE SCIENCE,16(8),392-402.
MLA Xu, Jian-Ping,et al."Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol".JOURNAL OF PEPTIDE SCIENCE 16.8(2010):392-402.
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