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学科主题: 临床医学
题名:
Antifungal Susceptibility and Phylogeny of Opportunistic Members of the Order Mucorales
作者: Vitale, Roxana G.1,2,3; de Hoog, G. Sybren1,4,5,6; Schwarz, Patrick7; Dannaoui, Eric7; Deng, Shuwen1; Machouart, Marie8; Voigt, Kerstin9,10,11; de Sande, Wendy W. J. van12; Dolatabadi, Somayeh1,4; Meis, Jacques F.13; Walther, Grit1,9,13
刊名: JOURNAL OF CLINICAL MICROBIOLOGY
发表日期: 2012
DOI: 10.1128/JCM.06133-11
卷: 50, 期:1, 页:66-75
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: IN-VITRO SUSCEPTIBILITIES ; AMPHOTERICIN-B ; RENAL ZYGOMYCOSIS ; FILAMENTOUS FUNGI ; RIBOSOMAL-DNA ; POSACONAZOLE ; ITRACONAZOLE ; VORICONAZOLE ; IDENTIFICATION ; STRAINS
英文摘要:

The in vitro susceptibilities of 66 molecularly identified strains of the Mucorales to eight antifungals (amphotericin B, terbinafine, itraconazole, posaconazole, voriconazole, caspofungin, micafungin, and 5-fluorocytosine) were tested. Molecular phylogeny was reconstructed based on the nuclear ribosomal large subunit to reveal taxon-specific susceptibility profiles. The impressive phylogenetic diversity of the Mucorales was reflected in susceptibilities differing at family, genus, and species levels. Amphotericin B was the most active drug, though somewhat less against Rhizopus and Cunninghamella species. Posaconazole was the second most effective antifungal agent but showed reduced activity in Mucor and Cunninghamella strains, while voriconazole lacked in vitro activity for most strains. Genera attributed to the Mucoraceae exhibited a wide range of MICs for posaconazole, itraconazole, and terbinafine and included resistant strains. Cunninghamella also comprised strains resistant to all azoles tested but was fully susceptible to terbinafine. In contrast, the Lichtheimiaceae completely lacked strains with reduced susceptibility for these antifungals. Syncephalastrum species exhibited susceptibility profiles similar to those of the Lichtheimiaceae. Mucor species were more resistant to azoles than Rhizopus species. Species-specific responses were obtained for terbinafine where only Rhizopus arrhizus and Mucor circinelloides were resistant. Complete or vast resistance was observed for 5-fluorocytosine, caspofungin, and micafungin. Intraspecific variability of in vitro susceptibility was found in all genera tested but was especially high in Mucor and Rhizopus for azoles and terbinafine. Accurate molecular identification of etiologic agents is compulsory to predict therapy outcome. For species of critical genera such as Mucor and Rhizopus, exhibiting high intraspecific variation, susceptibility testing before the onset of therapy is recommended.

语种: 英语
项目资助者: Gilead ; Janssen Pharmaceutica ; Merck ; Pfizer ; Schering-Plough
WOS记录号: WOS:000299996600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55475
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
2.CHU Brabois, Serv Parasitol Mycol, Nancy, France
3.Leibniz Inst Nat Product Res, Jena, Germany
4.Infect Biol Hans Knoll Inst, Jena, Germany
5.Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina
6.Ramos Mejia Hosp, Parasitol Unit, Mycol Sect, Buenos Aires, DF, Argentina
7.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
8.Sun Yat Sen Univ, Sun Yat Sen Hosp, Guangzhou 510275, Guangdong, Peoples R China
9.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
10.Ctr Natl Reference Mycol & Antifong, Inst Pasteur, Unite Mycol Mol, Paris, France
11.Univ Jena, Dept Microbiol & Mol Biol, Inst Microbiol, Jena, Germany
12.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
13.Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

Recommended Citation:
Vitale, Roxana G.,de Hoog, G. Sybren,Schwarz, Patrick,et al. Antifungal Susceptibility and Phylogeny of Opportunistic Members of the Order Mucorales[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2012,50(1):66-75.
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