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Reactive-oxygen-species-mediated Cdc25C degradation results in differential antiproliferative activities of vanadate, tungstate, and molybdate in the PC-3 human prostate cancer cell line
Liu, Tong-Tong1,2; Liu, Yan-Jun1; Wang, Qin1; Yang, Xiao-Gai1; Wang, Kui1,2
关键词Vanadate Tungstate Molybdate Cell Cycle Arrest Reactive Oxygen Species
刊名JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
2012-02-01
DOI10.1007/s00775-011-0852-1
17期:2页:311-320
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]VANADIUM COMPOUNDS ; GLUCOSE-METABOLISM ; OXIDATIVE STRESS ; PHOSPHATASE ; CYTOTOXICITY ; INHIBITION ; EXPRESSION ; APOPTOSIS ; PATHWAYS ; MITOSIS
英文摘要

The differential antiproliferative effects of vanadate, tungstate, and molybdate on human prostate cancer cell line PC-3 were compared and the underlying mechanisms were investigated. The results demonstrate that all of the three oxoanions can cause G2/M cell cycle arrest, which is evidenced by the increase in the level of phosphorylated Cdc2 at its inactive Tyr-15 site. Moreover, even if the difference in cellular uptake among the three oxoanions is excluded from the possible factors affecting their antiproliferative activity, vanadate exerted a much more potent effect in PC-3 cells than the other two oxoanions. Our results also reveal that reactive oxygen species (ROS)-mediated degradation of Cdc25C rather than Cdc25A or Cdc25B is responsible for vanadate-induced G2/M cell cycle arrest. We propose a possible mechanism to clarify the differential effect of the three oxoanions in biological systems beyond just considering that they are structural analogs of phosphate. We suggest that ROS formation is unlikely to be involved in the biological function of tungstate and molybdate, whereas the redox properties of vanadium may be important factors for it to exert pharmacological effects. Further, given the evidence from epidemiology studies of the association between diabetes and prostate cancer, the possibility of vanadate as a good candidate as both an antidiabetic and an anticancer agent or a chemopreventive agent is indicated.

语种英语
WOS记录号WOS:000301185800014
项目编号20871008 ; J0830836
资助机构National Natural Science Foundation of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55477
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Liu, Tong-Tong,Liu, Yan-Jun,Wang, Qin,et al. Reactive-oxygen-species-mediated Cdc25C degradation results in differential antiproliferative activities of vanadate, tungstate, and molybdate in the PC-3 human prostate cancer cell line[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2012,17(2):311-320.
APA Liu, Tong-Tong,Liu, Yan-Jun,Wang, Qin,Yang, Xiao-Gai,&Wang, Kui.(2012).Reactive-oxygen-species-mediated Cdc25C degradation results in differential antiproliferative activities of vanadate, tungstate, and molybdate in the PC-3 human prostate cancer cell line.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,17(2),311-320.
MLA Liu, Tong-Tong,et al."Reactive-oxygen-species-mediated Cdc25C degradation results in differential antiproliferative activities of vanadate, tungstate, and molybdate in the PC-3 human prostate cancer cell line".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 17.2(2012):311-320.
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