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miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2
Fu, Jing1,2; Xu, Xiaojie2; Kang, Lei3; Zhou, Liying2; Wang, Shibin4; Lu, Juming1; Cheng, Long2; Fan, Zhongyi2; Yuan, Bin2; Tian, Peirong1; Zheng, Xiaofei5; Yu, Chengze4; Ye, Qinong2; Lv, Zhaohui1
关键词Mir-30a Eya2 Breast Cancer Cell Proliferation Cell Migration
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2014-03-07
DOI10.1016/j.bbrc.2014.01.174
445期:2页:314-319
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者Major State Basic Research Development Program ; National Natural Science Foundation ; Major State Basic Research Development Program ; National Natural Science Foundation
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]EYES ABSENT ; COLORECTAL-CANCER ; EXPRESSION ; MICRORNA ; SPECIFICATION ; TRANSCRIPTION ; TRANSITION ; APOPTOSIS ; INVASION ; LINES
英文摘要

Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
所属项目编号2011CB504202 ; 2012CB945100 ; 81372161 ; 31100604 ; 81101065
资助者Major State Basic Research Development Program ; National Natural Science Foundation ; Major State Basic Research Development Program ; National Natural Science Foundation
WOS记录号WOS:000333228700009
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55488
专题北京大学第一临床医学院_核医学科
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Chinese PLA Med Sch, Dept Endocrinol, Beijing, Peoples R China
2.Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing 100850, Peoples R China
3.Peking Univ First Hosp, Dept Nucl Med, Beijing, Peoples R China
4.307 Hosp PLA, Dept Gen Surg, Beijing, Peoples R China
5.Beijing Inst Radiat Med, Beijing, Peoples R China
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GB/T 7714
Fu, Jing,Xu, Xiaojie,Kang, Lei,et al. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,445(2):314-319.
APA Fu, Jing.,Xu, Xiaojie.,Kang, Lei.,Zhou, Liying.,Wang, Shibin.,...&Lv, Zhaohui.(2014).miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,445(2),314-319.
MLA Fu, Jing,et al."miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 445.2(2014):314-319.
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