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学科主题: 临床医学
题名:
miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2
作者: Fu, Jing1,2; Xu, Xiaojie2; Kang, Lei3; Zhou, Liying2; Wang, Shibin4; Lu, Juming1; Cheng, Long2; Fan, Zhongyi2; Yuan, Bin2; Tian, Peirong1; Zheng, Xiaofei5; Yu, Chengze4; Ye, Qinong2; Lv, Zhaohui1
关键词: miR-30a ; Eya2 ; Breast cancer ; Cell proliferation ; Cell migration
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2014-03-07
DOI: 10.1016/j.bbrc.2014.01.174
卷: 445, 期:2, 页:314-319
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: EYES ABSENT ; COLORECTAL-CANCER ; EXPRESSION ; MICRORNA ; SPECIFICATION ; TRANSCRIPTION ; TRANSITION ; APOPTOSIS ; INVASION ; LINES
英文摘要:

Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2011CB504202 ; 2012CB945100 ; 81372161 ; 31100604 ; 81101065
项目资助者: Major State Basic Research Development Program ; National Natural Science Foundation
WOS记录号: WOS:000333228700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55488
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Chinese PLA Med Sch, Dept Endocrinol, Beijing, Peoples R China
2.Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing 100850, Peoples R China
3.Peking Univ First Hosp, Dept Nucl Med, Beijing, Peoples R China
4.307 Hosp PLA, Dept Gen Surg, Beijing, Peoples R China
5.Beijing Inst Radiat Med, Beijing, Peoples R China

Recommended Citation:
Fu, Jing,Xu, Xiaojie,Kang, Lei,et al. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,445(2):314-319.
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