IR@PKUHSC  > 北京大学第三临床医学院  > 消化科
学科主题临床医学
The intrinsic fluorescence spectrum of dilute gastric juice as a novel diagnostic tool for gastric cancer
Zhou, Li Ya1; Lin, San Ren1; Li, Yuan1; Geng, Qiu Ming2; Ding, Shi Gang1; Meng, Ling Mei1; Sun, Xiao Ning1; Wang, Jing Tong1; Xu, Zhi Jie1; Guo, Hui Lan1; Li, Cheng Gang1; Cui, Rong Li1
关键词Affected Factor Gastric Cancer Gastric Juice Intrinsic Fluorescence
刊名JOURNAL OF DIGESTIVE DISEASES
2011-08-01
DOI10.1111/j.1751-2980.2011.00507.x
12期:4页:279-285
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]BLOOD-SERUM ; SPECTROSCOPY ; AUTOFLUORESCENCE ; ULTRAVIOLET ; ENDOSCOPY
英文摘要

OBJECTIVE: To investigate the intrinsic fluorescence spectrum of gastric juice as a diagnostic method for gastric cancer.

METHODS: We collected gastric juice by gastroscopy in 1870 patients from May 2001 to March 2006, of whom 202 were involved in a preliminary test, 162 in experimental optimization and 1506 in clinical verification. The best dilution and pH value were chosen in the experimental optimization phase. Clinical verification was based on optimized samples. Intrinsic fluorescence spectra were measured in all samples with a fluorescence spectrophotometer using an excitation wavelength of 288 nm.

RESULTS: The first peak of fluorescence intensity (P(1)FI) of the intrinsic fluorescence spectrum was significantly higher in gastric juice from patients with gastric cancer than from those with benign lesions. There was no significant difference in the P1FI differences between patients with benign and malignant lesions with samples diluted by 20-fold to 80-fold and from pH 9 to pH 11. Clinical verification in 1506 patients showed that P(1)FI >= 76.5 was the optimal cutoff on the receiver operating characteristic curve for diagnosing gastric cancers: sensitivity was 83.2%, specificity 80.7% and accuracy 82.0%.

CONCLUSIONS: P(1)FI of the intrinsic fluorescence at 288 nm is significantly higher in patients with gastric cancers than in individuals with benign lesions. As a clinical indicator of gastric cancer, its sensitivity, specificity and accuracy were high.

语种英语
所属项目编号30371603 ; 30973415
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000293175400007
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55489
Collection北京大学第三临床医学院_消化科
作者单位1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Lab, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Li Ya,Lin, San Ren,Li, Yuan,et al. The intrinsic fluorescence spectrum of dilute gastric juice as a novel diagnostic tool for gastric cancer[J]. JOURNAL OF DIGESTIVE DISEASES,2011,12(4):279-285.
APA Zhou, Li Ya.,Lin, San Ren.,Li, Yuan.,Geng, Qiu Ming.,Ding, Shi Gang.,...&Cui, Rong Li.(2011).The intrinsic fluorescence spectrum of dilute gastric juice as a novel diagnostic tool for gastric cancer.JOURNAL OF DIGESTIVE DISEASES,12(4),279-285.
MLA Zhou, Li Ya,et al."The intrinsic fluorescence spectrum of dilute gastric juice as a novel diagnostic tool for gastric cancer".JOURNAL OF DIGESTIVE DISEASES 12.4(2011):279-285.
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