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学科主题: 临床医学
题名:
The intrinsic fluorescence spectrum of dilute gastric juice as a novel diagnostic tool for gastric cancer
作者: Zhou, Li Ya1; Lin, San Ren1; Li, Yuan1; Geng, Qiu Ming2; Ding, Shi Gang1; Meng, Ling Mei1; Sun, Xiao Ning1; Wang, Jing Tong1; Xu, Zhi Jie1; Guo, Hui Lan1; Li, Cheng Gang1; Cui, Rong Li1
关键词: affected factor ; gastric cancer ; gastric juice ; intrinsic fluorescence
刊名: JOURNAL OF DIGESTIVE DISEASES
发表日期: 2011-08-01
DOI: 10.1111/j.1751-2980.2011.00507.x
卷: 12, 期:4, 页:279-285
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: BLOOD-SERUM ; SPECTROSCOPY ; AUTOFLUORESCENCE ; ULTRAVIOLET ; ENDOSCOPY
英文摘要:

OBJECTIVE: To investigate the intrinsic fluorescence spectrum of gastric juice as a diagnostic method for gastric cancer.

METHODS: We collected gastric juice by gastroscopy in 1870 patients from May 2001 to March 2006, of whom 202 were involved in a preliminary test, 162 in experimental optimization and 1506 in clinical verification. The best dilution and pH value were chosen in the experimental optimization phase. Clinical verification was based on optimized samples. Intrinsic fluorescence spectra were measured in all samples with a fluorescence spectrophotometer using an excitation wavelength of 288 nm.

RESULTS: The first peak of fluorescence intensity (P(1)FI) of the intrinsic fluorescence spectrum was significantly higher in gastric juice from patients with gastric cancer than from those with benign lesions. There was no significant difference in the P1FI differences between patients with benign and malignant lesions with samples diluted by 20-fold to 80-fold and from pH 9 to pH 11. Clinical verification in 1506 patients showed that P(1)FI >= 76.5 was the optimal cutoff on the receiver operating characteristic curve for diagnosing gastric cancers: sensitivity was 83.2%, specificity 80.7% and accuracy 82.0%.

CONCLUSIONS: P(1)FI of the intrinsic fluorescence at 288 nm is significantly higher in patients with gastric cancers than in individuals with benign lesions. As a clinical indicator of gastric cancer, its sensitivity, specificity and accuracy were high.

语种: 英语
所属项目编号: 30371603 ; 30973415
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000293175400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55489
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Gastroenterol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Ctr Lab, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Li Ya,Lin, San Ren,Li, Yuan,et al. The intrinsic fluorescence spectrum of dilute gastric juice as a novel diagnostic tool for gastric cancer[J]. JOURNAL OF DIGESTIVE DISEASES,2011,12(4):279-285.
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