IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview
Wu, F; Wang, ZB; Chen, WZ; Wang, W; Gui, YZ; Zhang, M; Zheng, GQ; Zhou, YJ; Xu, GL; Li, M; Zhang, CW; Ye, HY; Feng, R
关键词High Intensity Focused Ultrasound Focused Ultrasound Surgery Neoplasm Ablation Therapeutic Ultrasound
刊名ULTRASONICS SONOCHEMISTRY
2004-05-01
DOI10.1016/j.ultsonch.2004.01.011
11期:3-4页:149-154
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Acoustics ; Chemistry, Multidisciplinary
研究领域[WOS]Acoustics ; Chemistry
英文摘要

The ideal treatment of localized cancer should directly cause an irreversible and complete death of tumor cells without damage to surrounding normal tissue. High intensity focused ultrasound (HIFU) is such a potential treatment, which induces a complete coagulative necrosis of a tumor at depth through the intact skin. The idea that using an extracorporeal source of therapeutic ultrasound was introduced more than 50 years ago [J. Gen. Physiol. 26 (1942) 179]. However, up to now, most of the studies on HIFU have been dealing with animal experiments because this extracorporeal technique is very complicated in clinical applications. The purpose of this study is to introduce Chinese clinical experience of using extracorporeal HIFU for the treatment of patients with various kinds of solid tumor. From December 1997 to October 2001, a total of 1038 patients with solid tumors underwent HIFU ablation in China. Among them, 313 patients were treated at the Chongqing University of Medical Sciences, China. Pathological examination showed that the target region presented clear evidence of cellular destruction. Small blood vessels less than 2 mm in diameter were severely damaged. Follow-up diagnostic imaging revealed that there was no, or reduced, blood supply, and no uptake of radioisotope in the treated tumor after HIFU, both indicating a positive therapeutic response and an absence of viable tumor. Imaging at 6-12 months showed obvious regression of the lesion. Four-year follow-up data were significantly observed in patients with hepatocellular carcinoma, osteosarcoma, and breast cancer. An extremely low major complication rate was noted. It is concluded that HIFU ablation is a safe, effective, and feasible modality for the ablation of carcinomas. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000221062200008
Citation statistics
Cited Times:173[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55492
Collection北京大学临床肿瘤学院
作者单位1.Guangzhou 1st Municipal Hosp, Guangzhou 510180, Peoples R China
2.Chongqing Univ, Affiliated Hosp 2, Clin Ctr Tumor Theraphy, Chongqing 400010, Peoples R China
3.Acad Mil Med Sci, Beijing Hosp 307, Beijing 100039, Peoples R China
4.Sichuan Univ, W China 4th Hosp, Chengdu 610041, Peoples R China
5.Jiangsu Canc Hosp, Nanjing 210009, Peoples R China
6.Peking Univ, Beijing Canc Hosp, Beijing 100036, Peoples R China
7.Sun Yat Sen Univ, Canc Hosp, Guangzhou 510062, Peoples R China
8.Shandong Canc Hosp, Jinan 250117, Peoples R China
9.Qinghai Med Univ, Affiliated Hosp, Xining 810001, Peoples R China
10.Beijing 301 Hosp, Beijing 100853, Peoples R China
11.Nanjing Univ, Inst Acoust, Nanjing 210093, Peoples R China
Recommended Citation
GB/T 7714
Wu, F,Wang, ZB,Chen, WZ,et al. Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview[J]. ULTRASONICS SONOCHEMISTRY,2004,11(3-4):149-154.
APA Wu, F.,Wang, ZB.,Chen, WZ.,Wang, W.,Gui, YZ.,...&Feng, R.(2004).Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview.ULTRASONICS SONOCHEMISTRY,11(3-4),149-154.
MLA Wu, F,et al."Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview".ULTRASONICS SONOCHEMISTRY 11.3-4(2004):149-154.
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