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An Efficient Four-Component, One-Pot Synthesis of Poly-Substituted Pyrimidines in Water
Wang Zhongqing; Ge Zemei; Cheng Tieming; Li Runtao
关键词Poly-substituted Pyrimidine Four-component One-pot Synthesis Environmentally Friendly Aqueous Medium
刊名CHINESE JOURNAL OF CHEMISTRY
2009-04-01
27期:4页:834-838
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
资助者National Natural Science Foundation of China ; Major State Basic Research Development Program ; National Natural Science Foundation of China ; Major State Basic Research Development Program
研究领域[WOS]Chemistry
关键词[WOS]BIOLOGICAL EVALUATION ; KETENE DITHIOACETALS ; RECEPTORS ; LIGANDS ; HETEROCYCLES ; DERIVATIVES ; INHIBITION ; DESIGN ; ABL
英文摘要

An efficient environmentally friendly synthesis of poly-substituted pyrimidines has been developed via a four-component, one-pot reaction of malononitrile, carbon disulfide, alkyl halide and S-alkylisothiouronium salt in water at room temperature. Water as solvent, mild reaction conditions, short reaction time, simple experimental procedures, broad scope of substrates and good yields are the main advantages of this method.

语种英语
所属项目编号20672009 ; 2004CB719900
资助者National Natural Science Foundation of China ; Major State Basic Research Development Program ; National Natural Science Foundation of China ; Major State Basic Research Development Program
WOS记录号WOS:000265717900039
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55493
专题北京大学药学院
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang Zhongqing,Ge Zemei,Cheng Tieming,et al. An Efficient Four-Component, One-Pot Synthesis of Poly-Substituted Pyrimidines in Water[J]. CHINESE JOURNAL OF CHEMISTRY,2009,27(4):834-838.
APA Wang Zhongqing,Ge Zemei,Cheng Tieming,&Li Runtao.(2009).An Efficient Four-Component, One-Pot Synthesis of Poly-Substituted Pyrimidines in Water.CHINESE JOURNAL OF CHEMISTRY,27(4),834-838.
MLA Wang Zhongqing,et al."An Efficient Four-Component, One-Pot Synthesis of Poly-Substituted Pyrimidines in Water".CHINESE JOURNAL OF CHEMISTRY 27.4(2009):834-838.
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