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学科主题: 临床医学
题名:
Role of hepatitis B virus base core and precore/core promoter mutations on hepatocellular carcinoma in untreated older genotype C Chinese patients
作者: Zheng, J-X.; Zeng, Z.; Zheng, Y. Y.; Yin, S-J.; Zhang, D-Y.; Yu, Y-Y.; Wang, F.
关键词: basal core promoter mutants ; HBV genotypes ; hepatocellular carcinoma ; precore mutants
刊名: JOURNAL OF VIRAL HEPATITIS
发表日期: 2011-10-01
DOI: 10.1111/j.1365-2893.2011.01458.x
卷: 18, 期:10, 页:E423-E431
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]: VIRAL LOAD ; DISEASE PROGRESSION ; GENE-EXPRESSION ; REPLICATION ; INFECTION ; RISK ; CIRRHOSIS ; CARRIERS ; REACTIVATION ; PREVENTION
英文摘要:

The aim of the study was to investigate the prevalence of mutations of basal core promoter (BCP) and precore (PreC) region of hepatitis B virus (HBV) and their association with hepatocellular carcinoma. A total of 341 untreated older HBV patients were divided into three groups: chronic hepatitis B (CHB, 185), cirrhotic hepatocellular carcinoma (LC-HCC, 113) and non-cirrhotic hepatocellular carcinoma (non-LC-HCC, 43). HBV BCP and PreC mutations and genotypes were determined by direct sequencing. Using univariate analysis, age (>= 45 years), single mutations including A1896 and A1899 and multiple mutations T1762/A1764 + A1896, T1762/A1764 + A1899 and T1762/A1764 + A1896 + A1899 were more frequently detected in LC-HCC and non-LC-HCC patients than in CHB patients. BCP T1762/A1764 mutations were highly detected in LC-HCC patients than in CHB patients. Multivariate logistic regression analysis (adjusted for age and gender) revealed that among HBeAg-positive patients, BCP T1762/A1764 mutations (OR, 5.975; P = 0.05), PreC A1899 mutation (OR, 4.180; P = 0.013) and multiple mutations T1762/A1764 + A1899 (OR, 6.408; P = 0.006) were independently associated with the development of LC-HCC; PreC A1899 mutation (OR, 7.347; P = 0.034) was also independently associated with the development of non-LC-HCC. On the other hand, among HBeAg-negative patients, PreC A1896 mutation (OR, 5.176; P = 0.002) and multiple mutations T1762/A1764 + A1896 (OR, 4.149; P = 0.007) were independently associated with the development of non-LC-HCC. These results indicated that older age (>= 45 years) was associated with LC-HCC and non-LC-HCC development. BCP T1762/A1764 mutations and PreC A1899 mutation were associated with the LC-HCC development in HBeAg-positive patients. PreC A1896 mutation was associated with the non-LC-HCC development in HBeAg-negative patients.

语种: 英语
所属项目编号: 30671855 ; N01-CO-12400
项目资助者: National Nature Science Foundation of China ; National Cancer Institute ; National Institute of Health
WOS记录号: WOS:000295091500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55494
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: Peking Univ, Dept Infect Dis, Virol Lab, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zheng, J-X.,Zeng, Z.,Zheng, Y. Y.,et al. Role of hepatitis B virus base core and precore/core promoter mutations on hepatocellular carcinoma in untreated older genotype C Chinese patients[J]. JOURNAL OF VIRAL HEPATITIS,2011,18(10):E423-E431.
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