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学科主题: 临床医学
题名:
MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells
作者: Zeng, Yan1,2; Pan, Yanping1; Liu, Hongtai1; Kang, Kang1; Wu, Yike1; Hui, Gang3; Peng, Wenda2; Ramchandran, Ramaswamy4; Raj, J. Usha4; Gou, Deming1,4
关键词: MicroRNA ; cGMP-dependent protein kinase ; Coding region ; Pulmonary arterial smooth muscle cells ; Hypoxia
刊名: FEBS LETTERS
发表日期: 2014-12-20
DOI: 10.1016/j.febslet.2014.10.040
卷: 588, 期:24, 页:4677-4685
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: DEPENDENT PROTEIN-KINASE ; BONE MORPHOGENETIC PROTEIN ; GROWTH-FACTOR-BETA ; CYCLIC-GMP ; POSTTRANSCRIPTIONAL REGULATION ; PHENOTYPIC MODULATION ; MICRORNA TARGETS ; HYPERTENSION ; EXPRESSION ; RECEPTOR
英文摘要:

Chronic hypoxia triggers pulmonary vascular remodeling, which is associated with de-differentiation of pulmonary artery smooth muscle cells (PASMC). Here, we show that miR-20a expression is up-regulated in response to hypoxia in both mouse and human PASMC. We also observed that miR-20a represses the protein kinase, cGMP-dependent, type I (PRKG1) gene and we identified two crucial miR-20a binding sites within the coding region of PRKG1. Functional studies showed that miR-20a promotes the proliferation and migration of human PASMC, whereas it inhibits their differentiation. In summary, we provided a possible mechanism by which hypoxia results in decreased PRKG1 expression and in the phenotypic switching of PASMC. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81170047 ; 81370151 ; 2012CB124701 ; YFZZ20111009
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Shenzhen overseas high-level talents innovation program
WOS记录号: WOS:000346577000021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55496
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shenzhen Univ, Coll Life Sci, Shenzhen Key Lab Microbial Genet Engn, Shenzhen 518060, Guangdong, Peoples R China
2.Shenzhen Univ, Coll Optoelect Engn, Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst, Shenzhen 518060, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Chest Surg, Shenzhen 518000, Guangdong, Peoples R China
4.Univ Illinois, Dept Pediat, Chicago, IL 60612 USA

Recommended Citation:
Zeng, Yan,Pan, Yanping,Liu, Hongtai,et al. MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells[J]. FEBS LETTERS,2014,588(24):4677-4685.
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