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MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells
Zeng, Yan1,2; Pan, Yanping1; Liu, Hongtai1; Kang, Kang1; Wu, Yike1; Hui, Gang3; Peng, Wenda2; Ramchandran, Ramaswamy4; Raj, J. Usha4; Gou, Deming1,4
关键词Microrna Cgmp-dependent Protein Kinase Coding Region Pulmonary Arterial Smooth Muscle Cells Hypoxia
刊名FEBS LETTERS
2014-12-20
DOI10.1016/j.febslet.2014.10.040
588期:24页:4677-4685
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]DEPENDENT PROTEIN-KINASE ; BONE MORPHOGENETIC PROTEIN ; GROWTH-FACTOR-BETA ; CYCLIC-GMP ; POSTTRANSCRIPTIONAL REGULATION ; PHENOTYPIC MODULATION ; MICRORNA TARGETS ; HYPERTENSION ; EXPRESSION ; RECEPTOR
英文摘要

Chronic hypoxia triggers pulmonary vascular remodeling, which is associated with de-differentiation of pulmonary artery smooth muscle cells (PASMC). Here, we show that miR-20a expression is up-regulated in response to hypoxia in both mouse and human PASMC. We also observed that miR-20a represses the protein kinase, cGMP-dependent, type I (PRKG1) gene and we identified two crucial miR-20a binding sites within the coding region of PRKG1. Functional studies showed that miR-20a promotes the proliferation and migration of human PASMC, whereas it inhibits their differentiation. In summary, we provided a possible mechanism by which hypoxia results in decreased PRKG1 expression and in the phenotypic switching of PASMC. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000346577000021
项目编号81170047 ; 81370151 ; 2012CB124701 ; YFZZ20111009
资助机构National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; Shenzhen overseas high-level talents innovation program
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55496
专题北京大学深圳医院
作者单位1.Shenzhen Univ, Coll Life Sci, Shenzhen Key Lab Microbial Genet Engn, Shenzhen 518060, Guangdong, Peoples R China
2.Shenzhen Univ, Coll Optoelect Engn, Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst, Shenzhen 518060, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Chest Surg, Shenzhen 518000, Guangdong, Peoples R China
4.Univ Illinois, Dept Pediat, Chicago, IL 60612 USA
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GB/T 7714
Zeng, Yan,Pan, Yanping,Liu, Hongtai,et al. MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells[J]. FEBS LETTERS,2014,588(24):4677-4685.
APA Zeng, Yan.,Pan, Yanping.,Liu, Hongtai.,Kang, Kang.,Wu, Yike.,...&Gou, Deming.(2014).MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.FEBS LETTERS,588(24),4677-4685.
MLA Zeng, Yan,et al."MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells".FEBS LETTERS 588.24(2014):4677-4685.
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