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Poly(acrylic acid) microspheres loaded with lidocaine: Preparation and characterization for arterial embolization
Cui, Dai-Chao; Lu, Wan-Liang; Sa, Er-A; Gu, Meng-Jie; Lu, Xiao-Jing; Fan, Tian-Yuan
关键词Poly(Acrylic Acid) Microspheres Embolization Lidocaine Sustained Release
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
2012-10-15
DOI10.1016/j.ijpharm.2012.07.020
436期:1-2页:527-535
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TRIS-ACRYL GELATIN ; UTERINE FIBROID EMBOLIZATION ; POLYVINYL-ALCOHOL MICROSPHERES ; DRUG ELUTING BEADS ; IN-VITRO ; RELEASE ; CHEMOEMBOLIZATION ; PAIN ; VIVO ; POLYMERIZATION
英文摘要

A new embolic agent, poly(acrylic acid) microspheres (PMs), was synthesized and the cytocompatibility was proved by mouse L929 fibroblast cells. An analgesic drug, lidocaine, was loaded on the PMs to relief pain caused by embolization. PMs and lidocaine loaded microspheres (LMs) were characterized by investigating infrared spectrum, morphology, particle size, and equilibrium water contents (EWC). A series of tests were employed to evaluate the elasticity of PMs, LMs and Embosphere (TM), including once compression, twice compression, and stress relaxation test. The pressures of PMs and LMs passing through a catheter were measured on line by our new designed device. Drug release was studied with T-cell apparatus. The properties of PMs and LMs were proved to be suitable for embolization. Both PMs and LMs in this study might be potential embolic agents in the future. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000308597600057
项目编号2009ZX09310-001
资助机构State Key Projects
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55501
专题北京大学药学院_药剂学系
作者单位Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Cui, Dai-Chao,Lu, Wan-Liang,Sa, Er-A,et al. Poly(acrylic acid) microspheres loaded with lidocaine: Preparation and characterization for arterial embolization[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2012,436(1-2):527-535.
APA Cui, Dai-Chao,Lu, Wan-Liang,Sa, Er-A,Gu, Meng-Jie,Lu, Xiao-Jing,&Fan, Tian-Yuan.(2012).Poly(acrylic acid) microspheres loaded with lidocaine: Preparation and characterization for arterial embolization.INTERNATIONAL JOURNAL OF PHARMACEUTICS,436(1-2),527-535.
MLA Cui, Dai-Chao,et al."Poly(acrylic acid) microspheres loaded with lidocaine: Preparation and characterization for arterial embolization".INTERNATIONAL JOURNAL OF PHARMACEUTICS 436.1-2(2012):527-535.
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