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学科主题: 药学
题名:
Poly(acrylic acid) microspheres loaded with lidocaine: Preparation and characterization for arterial embolization
作者: Cui, Dai-Chao; Lu, Wan-Liang; Sa, Er-A; Gu, Meng-Jie; Lu, Xiao-Jing; Fan, Tian-Yuan
关键词: Poly(acrylic acid) ; Microspheres ; Embolization ; Lidocaine ; Sustained release
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2012-10-15
DOI: 10.1016/j.ijpharm.2012.07.020
卷: 436, 期:1-2, 页:527-535
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TRIS-ACRYL GELATIN ; UTERINE FIBROID EMBOLIZATION ; POLYVINYL-ALCOHOL MICROSPHERES ; DRUG ELUTING BEADS ; IN-VITRO ; RELEASE ; CHEMOEMBOLIZATION ; PAIN ; VIVO ; POLYMERIZATION
英文摘要:

A new embolic agent, poly(acrylic acid) microspheres (PMs), was synthesized and the cytocompatibility was proved by mouse L929 fibroblast cells. An analgesic drug, lidocaine, was loaded on the PMs to relief pain caused by embolization. PMs and lidocaine loaded microspheres (LMs) were characterized by investigating infrared spectrum, morphology, particle size, and equilibrium water contents (EWC). A series of tests were employed to evaluate the elasticity of PMs, LMs and Embosphere (TM), including once compression, twice compression, and stress relaxation test. The pressures of PMs and LMs passing through a catheter were measured on line by our new designed device. Drug release was studied with T-cell apparatus. The properties of PMs and LMs were proved to be suitable for embolization. Both PMs and LMs in this study might be potential embolic agents in the future. (c) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009ZX09310-001
项目资助者: State Key Projects
WOS记录号: WOS:000308597600057
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55501
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Cui, Dai-Chao,Lu, Wan-Liang,Sa, Er-A,et al. Poly(acrylic acid) microspheres loaded with lidocaine: Preparation and characterization for arterial embolization[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2012,436(1-2):527-535.
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