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学科主题临床医学
Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma
Yang, Hang1,2; Jiang, Wen-Qi1,2; Cao, Ye1,3; Sun, Yong-An4; Wei, Jing5; An, Xin1,2; Zhang, Ying-Chun1,6; Song, Ming1,7; Wang, Shu-Sen1,2; Yuan, Zhong-Yu1,2; Peng, Rou-Jun1,2; Chen, Tan-Huan8; Li, Li-Ren1,9; Shi, Yan-Xia1,2
刊名DISEASE MARKERS
2015
DOI10.1155/2015/640263
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental ; Pathology
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine ; Pathology
关键词[WOS]CHROMOSOME ARM 8P ; BREAST-CANCER ; PROGRESSION ; STATISTICS ; ONCOGENES ; AMPLICON ; FAMILY ; GENES
英文摘要

Aim. Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear. The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC. Methods. Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected. The expression of the ZNF703 protein was tested by immunohistochemistry (IHC). Results. The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P < 0.001). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P < 0.05). Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P = 0.022, hazard ratio = 1.635, 95% CI 1.073-2.493) in HNSCC patients. Conclusion. ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.

语种英语
WOS记录号WOS:000355478600001
项目编号2012AA02A501
资助机构Scientific Research Foundation for the Returned Overseas Chinese Scholars of Sun Yat-Sen University Cancer Center ; National High Technology Research and Development Program of China (863 Program)
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55508
专题北京大学第一临床医学院_神经内科
北京大学第一临床医学院_小儿眼科
作者单位1.Huizhou Municipal Cent Hosp, Dept Oncol, Huizhou 516001, Peoples R China
2.Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510060, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Ctr Canc, Clin Trial Ctr, Guangzhou 510060, Guangdong, Peoples R China
5.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
6.Guangxi Tradit Chinese Med Univ, Ruikang Hosp, Dept Med Oncol, Nanning 530011, Peoples R China
7.Sun Yat Sen Univ, Ctr Canc, Dept Pathol, Guangzhou 510060, Guangdong, Peoples R China
8.Sun Yat Sen Univ, Ctr Canc, Dept Head & Neck Surg, Guangzhou 510060, Guangdong, Peoples R China
9.Sun Yat Sen Univ, Ctr Canc, Dept Colorectal Surg, Guangzhou 510060, Guangdong, Peoples R China
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Yang, Hang,Jiang, Wen-Qi,Cao, Ye,et al. Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma[J]. DISEASE MARKERS,2015.
APA Yang, Hang.,Jiang, Wen-Qi.,Cao, Ye.,Sun, Yong-An.,Wei, Jing.,...&Shi, Yan-Xia.(2015).Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma.DISEASE MARKERS.
MLA Yang, Hang,et al."Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma".DISEASE MARKERS (2015).
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