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学科主题: 药物依赖
题名:
GABA(B) receptor agonist baclofen attenuates the development and expression of d-methamphetamine-induced place preference in rats
作者: Li, SM; Yin, LL; Ren, YH; Pan, LS; Zheng, JW
关键词: baclofen ; GABA(B) receptor ; d-methamphetamine ; conditioned place preference
刊名: LIFE SCIENCES
发表日期: 2001-12-07
卷: 70, 期:3, 页:349-356
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: VENTRAL TEGMENTAL AREA ; DUAL-PROBE MICRODIALYSIS ; DOPAMINE RELEASE ; NUCLEUS-ACCUMBENS ; PREFRONTAL CORTEX ; COCAINE ; NEURONS ; REWARD ; BRAIN ; PHARMACOLOGY
英文摘要:

The present study investigated the effect of systemic administration of the GABAB receptor agonist, baclofen, on the development and expression of d-methamphetamine (d-MA)-induced place preference in male Wistar rats. Using a biased and 8-day schedule of conditioning, it was found that administration of d-MA (0.5 mg/kg, IP) produced significant place preference. The administration of baclofen (2.5 and 5.0 mg/kg, IP) 30 min prior to the exposure to d-MA attenuated the development of d-MA-induced place preference (p<0.05). In addition, when it was acutely administered 30 min prior to the testing session of an already established d-MA place preference, baclofen (1.25-5.0 mg/kg, IP) attenuated the expression of this conditioned response in a dose-dependent manner. These results showed that baclofen suppressed the rewarding effect produced by d-MA and may be potentially effective in the treatment of methamphetamine dependence and craving. (C) 2001 Elsevier Science Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000172636400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55513
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China

Recommended Citation:
Li, SM,Yin, LL,Ren, YH,et al. GABA(B) receptor agonist baclofen attenuates the development and expression of d-methamphetamine-induced place preference in rats[J]. LIFE SCIENCES,2001,70(3):349-356.
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