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学科主题: 药学
题名:
Proteome studies on liver tissue in a phenobarbital-induced rat model
作者: Wu, Qian1,2; Zhang, Yong-He3; Zhao, Xin1,2; Shi, Wan-Lu1,2; Pu, Xiao-Ping1,2
关键词: Cytochrome P450 ; Drug interaction ; Liver ; Phenobarbital induction ; Two-dimensional electrophoresis ; Proteome ; Liver tissue ; Phenobarbital
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2011-11-30
DOI: 10.1016/j.ejphar.2011.09.161
卷: 670, 期:2-3, 页:333-340
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: NUCLEAR RECEPTORS ; CYTOCHROME-P450 INDUCTION ; OXIDATIVE STRESS ; DRUG-METABOLISM ; GENE-EXPRESSION ; THYROID-HORMONE ; QUINOLINIC ACID ; PEROXIREDOXIN 5 ; ACTIVATION ; CAR
英文摘要:

Many drugs may affect the activity of cytochrome P450 (CYP), which is a major source of adverse drug interactions (ADR). Phenobarbital (PB) is the typical inducer of cytochrome P450. The aim of our study was to determine the changes in the cytosolic proteins expression in rat liver at a protein level following induction of cytochrome P450. Firstly, we made a phenobarbital-induced cytochrome P450 rat model. The total cytosolic proteins were then extracted from rat liver tissue and separated by 2-D gel electrophoresis (2-DE). Differentially expressed spots were identified by MALDI-TOF/TOF tandem mass spectrometry followed by database searching. Eight differentially expressed proteins were identified and these proteins were found to be involved in protein degradation, oxidative stress, energy metabolism, biotransformation, and the synthesis of quinolinic acid (QUIN). These findings should provide useful information for research into the regulation of cytochrome P450 gene expression, drug metabolism and drug interaction. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2004CB518902
项目资助者: National Program for Key Basic Research Projects
WOS记录号: WOS:000297449000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55514
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Wu, Qian,Zhang, Yong-He,Zhao, Xin,et al. Proteome studies on liver tissue in a phenobarbital-induced rat model[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2011,670(2-3):333-340.
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