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学科主题: 临床医学
题名:
Combined analysis of AFP and HCCR-1 as an useful serological marker for small hepatocellular carcinoma: A prospective cohort study
作者: Zhang, Guoxin1; Ha, Seon-Ah2; Kim, Hyun K.2; Yoo, Jinah2; Kim, Sanghee2; Lee, Youn S.3; Hur, Soo Y.4; Kim, Yong W.4; Kim, Tae E.4; Park, Yong G.5; Wang, Jing1; Yang, Yang1; Xu, Zekuan1; Song, Eun Y.6; Huang, Zuhu1; Peng Jirun7; Jin Zhongtian7; Qiao Shishi7; Cui Zhuqingqing7; Lei, Gong7; Kim, Jin W.2,4
关键词: Hepatocellular carcinoma ; biomarker ; AFP ; HCCR-1
刊名: DISEASE MARKERS
发表日期: 2012
DOI: 10.3233/DMA-2011-0878
卷: 32, 期:4, 页:265-271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental ; Pathology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine ; Pathology
关键词[WOS]: ALPHA-FETOPROTEIN ; ONCOGENE HCCR-2 ; CANCER ; EXPRESSION ; DIAGNOSIS ; INDUCTION ; SURVIVAL
英文摘要:

Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors in the world. The only serological marker widely used for the diagnosis of HCC is alpha-fetoprotein (AFP). Despite that AFP is widely used for the diagnosis of HCC, it has a limit as a serological marker due to its low sensitivity and specificity. The human cervical cancer proto-oncogene 1 (HCCR-1) was previously reported as a new biomarker for HCC. To further evaluate the HCCR-1 as a biomarker for HCC, we conducted the prospective cohort study. We evaluated the significance of simultaneous measurement of 2 tumor markers in the diagnosis of HCC in China, Japan and Korea. Two markers for HCC, AFP and HCCR-1, were measured in the sera obtained from 1,338 patients at the time of initial diagnosis of HCC. Of the 1338 HCC patients, 616 (46%) and 686 (51.3%) were sero-positive for AFP and HCCR-1, respectively. The positive rate for HCC was increased up to 74.1% in combined use of AFP and HCCR-1. Many cases (54%) for AFP-negative HCC were positive for HCCR-1 and vice versa. More importantly, the diagnostic rate for small HCC (< 2 cm) was significantly improved in the combined analysis of AFP and HCCR-1 to 56.9% although it was only 40.1% and 23.4% in the single analysis of HCCR-1 and AFP, respectively. Our result suggests that the HCCR-1 could be an useful biomarker for HCC while the diagnostic rate could be significantly improved in the combined use of HCCR-1 and AFP.

语种: 英语
所属项目编号: 02-PJ10-PG6-AG01-0003
项目资助者: Seoul RBD Program ; Ministry of Health &amp ; Welfare, Republic of Korea
WOS记录号: WOS:000301947100007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55516
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Nanjing Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanjing, Jiangsu, Peoples R China
2.Catholic Univ Korea, Dept Mol Genet Lab, Coll Med, Seoul, South Korea
3.Catholic Univ Korea, Dept Clin Pathol, Coll Med, Seoul 137040, South Korea
4.Catholic Univ Korea, Dept Obstet & Gynecol, Coll Med, Seoul 137040, South Korea
5.Catholic Univ Korea, Dept Biostat, Coll Med, Seoul 137040, South Korea
6.Korea Res Inst Biosci & Biotechnol, Taejon, South Korea
7.Peking Univ, Peoples Hosp, Dept Hepatobiliary, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Guoxin,Ha, Seon-Ah,Kim, Hyun K.,et al. Combined analysis of AFP and HCCR-1 as an useful serological marker for small hepatocellular carcinoma: A prospective cohort study[J]. DISEASE MARKERS,2012,32(4):265-271.
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