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Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins
Zheng, Jiao1,2; Wang, Xianwei; Li, Haixia1; Gu, Yueqing2; Tu, Pengfei1,2; Wen, Zongyao3
关键词Hypercholesterolemia Ilex Kudingcha Total Saponins Hemorheology
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2009
DOI10.3233/CH-2009-1183
42期:1页:29-36
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
资助者National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University ; Institute of Cardiovascular Science of Peking University Health Science Center ; National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University ; Institute of Cardiovascular Science of Peking University Health Science Center
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]PLASMA VISCOSITY ; HEART-DISEASE ; RISK-FACTOR ; APOLIPOPROTEIN-E ; BLOOD RHEOLOGY ; HYPERLIPOPROTEINEMIA ; HYPERCHOLESTEROLEMIA ; ATORVASTATIN ; MICROCIRCULATION ; LOVASTATIN
英文摘要

The aim of this study was to test the effects of Ilex kudingcha total saponins on hemorheology of ApoE-/- mice suffering from hypercholesterolemia induced by high-cholesterol diet. The mice were randomly divided into six groups: the control group, the high-cholesterol diet group, 50 mg/kg atorvastatin treatment group, 75, 150 and 300 mg/kg Ilex kudingcha saponins treatment groups, and all the drug treatment groups were fed with a high-cholesterol diet. After administration with saponins (150 mg/kg or more) and atorvastatin (50 mg/kg) for six weeks, the plasma total cholesterol (TC), whole blood viscosity (WBV), plasma viscosity (PV), and erythrocyte aggregation index (EAI) had a remarkable decrease compared with that of the high-cholesterol diet group, but the hematocrit (Hct) and erythrocyte deformation index (DI) had no significant changes. In addition, it is found that the improving effects of saponins on reducing plasma fibrinogen (Fg) levels and prolonging the blood coagulation times including activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). In conclusion, the Ilex kudingcha total saponins may have a significant therapy application of hypercholesterolemia and atherosclerosis by considering its actions on hemorheological characteristics.

语种英语
所属项目编号30672608 ; 985-2-063-112
资助者National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University ; Institute of Cardiovascular Science of Peking University Health Science Center ; National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University ; Institute of Cardiovascular Science of Peking University Health Science Center
WOS记录号WOS:000265997600004
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55519
Collection北京大学药学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biophys,Hemorheol Ctr, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Jiao,Wang, Xianwei,Li, Haixia,et al. Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2009,42(1):29-36.
APA Zheng, Jiao,Wang, Xianwei,Li, Haixia,Gu, Yueqing,Tu, Pengfei,&Wen, Zongyao.(2009).Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,42(1),29-36.
MLA Zheng, Jiao,et al."Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 42.1(2009):29-36.
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