IR@PKUHSC  > 北京大学药学院
学科主题药学
Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins
Zheng, Jiao1,2; Wang, Xianwei; Li, Haixia1; Gu, Yueqing2; Tu, Pengfei1,2; Wen, Zongyao3
关键词Hypercholesterolemia Ilex Kudingcha Total Saponins Hemorheology
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2009
DOI10.3233/CH-2009-1183
42期:1页:29-36
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]PLASMA VISCOSITY ; HEART-DISEASE ; RISK-FACTOR ; APOLIPOPROTEIN-E ; BLOOD RHEOLOGY ; HYPERLIPOPROTEINEMIA ; HYPERCHOLESTEROLEMIA ; ATORVASTATIN ; MICROCIRCULATION ; LOVASTATIN
英文摘要

The aim of this study was to test the effects of Ilex kudingcha total saponins on hemorheology of ApoE-/- mice suffering from hypercholesterolemia induced by high-cholesterol diet. The mice were randomly divided into six groups: the control group, the high-cholesterol diet group, 50 mg/kg atorvastatin treatment group, 75, 150 and 300 mg/kg Ilex kudingcha saponins treatment groups, and all the drug treatment groups were fed with a high-cholesterol diet. After administration with saponins (150 mg/kg or more) and atorvastatin (50 mg/kg) for six weeks, the plasma total cholesterol (TC), whole blood viscosity (WBV), plasma viscosity (PV), and erythrocyte aggregation index (EAI) had a remarkable decrease compared with that of the high-cholesterol diet group, but the hematocrit (Hct) and erythrocyte deformation index (DI) had no significant changes. In addition, it is found that the improving effects of saponins on reducing plasma fibrinogen (Fg) levels and prolonging the blood coagulation times including activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). In conclusion, the Ilex kudingcha total saponins may have a significant therapy application of hypercholesterolemia and atherosclerosis by considering its actions on hemorheological characteristics.

语种英语
WOS记录号WOS:000265997600004
项目编号30672608 ; 985-2-063-112
资助机构National Natural Science Foundation of China ; Changjiang Scholar and Innovative Team in University ; Institute of Cardiovascular Science of Peking University Health Science Center
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55519
专题北京大学药学院
北京大学药学院_天然药物学系
北京大学第一临床医学院_检验科
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biophys,Hemorheol Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Jiao,Wang, Xianwei,Li, Haixia,et al. Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2009,42(1):29-36.
APA Zheng, Jiao,Wang, Xianwei,Li, Haixia,Gu, Yueqing,Tu, Pengfei,&Wen, Zongyao.(2009).Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,42(1),29-36.
MLA Zheng, Jiao,et al."Improving abnormal hemorheological parameters in ApoE-/- mice by Ilex kudingcha total saponins".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 42.1(2009):29-36.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zheng, Jiao]的文章
[Wang, Xianwei]的文章
[Li, Haixia]的文章
百度学术
百度学术中相似的文章
[Zheng, Jiao]的文章
[Wang, Xianwei]的文章
[Li, Haixia]的文章
必应学术
必应学术中相似的文章
[Zheng, Jiao]的文章
[Wang, Xianwei]的文章
[Li, Haixia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。