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学科主题: 药学
题名:
Template synthesis of peptidomimetics composed of aspartic acid moiety by Ugi four-component condensation reaction
作者: Zhang, X; Zou, XM; Xu, P
关键词: aspartic acid ; isocyanide ; peptidomimetics ; Ugi four-component reaction ; (Ugi-4CR)
刊名: SYNTHETIC COMMUNICATIONS
发表日期: 2005
DOI: 10.1081/SCC-200064913
卷: 35, 期:14, 页:1881-1888
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: APOPTOSIS ; ICE
英文摘要:

Caspase-3 inhibitors were supposed to be of benefit to both acute and chronic neurodegenerative conditions. In this work, a CPP32-peptidomimetic-inhibitor library was designed. The necessary aspartate moiety was reserved at the C terminal. A facile and versatile method based on Ugi-4CR was developed to build up the library. The aspartic acid-derived isocyanide 3, the most important component of the four, was effectively synthesized from protected aspartic acid. This Ugi procedure was tested by synthesizing a small library.

语种: 英语
WOS记录号: WOS:000230585500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55520
Appears in Collections:北京大学药学院_药物化学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, X,Zou, XM,Xu, P. Template synthesis of peptidomimetics composed of aspartic acid moiety by Ugi four-component condensation reaction[J]. SYNTHETIC COMMUNICATIONS,2005,35(14):1881-1888.
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