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Template synthesis of peptidomimetics composed of aspartic acid moiety by Ugi four-component condensation reaction
Zhang, X; Zou, XM; Xu, P
关键词Aspartic Acid Isocyanide Peptidomimetics Ugi Four-component Reaction (Ugi-4cr)
刊名SYNTHETIC COMMUNICATIONS
2005
DOI10.1081/SCC-200064913
35期:14页:1881-1888
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]APOPTOSIS ; ICE
英文摘要

Caspase-3 inhibitors were supposed to be of benefit to both acute and chronic neurodegenerative conditions. In this work, a CPP32-peptidomimetic-inhibitor library was designed. The necessary aspartate moiety was reserved at the C terminal. A facile and versatile method based on Ugi-4CR was developed to build up the library. The aspartic acid-derived isocyanide 3, the most important component of the four, was effectively synthesized from protected aspartic acid. This Ugi procedure was tested by synthesizing a small library.

语种英语
WOS记录号WOS:000230585500004
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55520
专题北京大学药学院_药物化学系
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, X,Zou, XM,Xu, P. Template synthesis of peptidomimetics composed of aspartic acid moiety by Ugi four-component condensation reaction[J]. SYNTHETIC COMMUNICATIONS,2005,35(14):1881-1888.
APA Zhang, X,Zou, XM,&Xu, P.(2005).Template synthesis of peptidomimetics composed of aspartic acid moiety by Ugi four-component condensation reaction.SYNTHETIC COMMUNICATIONS,35(14),1881-1888.
MLA Zhang, X,et al."Template synthesis of peptidomimetics composed of aspartic acid moiety by Ugi four-component condensation reaction".SYNTHETIC COMMUNICATIONS 35.14(2005):1881-1888.
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