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Intrathyroid epithelial thymoma (ITET) and carcinoma showing thymus-like differentiation (CASTLE). CD5-positive neoplasms mimicking squamous cell carcinoma of the thyroid
Kakudo, Kennichi1,2; Bai, Yanhua3; Ozaki, Takashi2; Homma, Kei-ichi4; Ito, Yasuhiro5; Miyauchi, Akira5
关键词Thyroid Carcinoma Cd5 Squamous Cell Lymphoepithelioma Neuroendocrine
刊名HISTOLOGY AND HISTOPATHOLOGY
2013-05-01
28期:5页:543-556
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]NEUROENDOCRINE DIFFERENTIATION ; CD5 IMMUNOREACTIVITY ; MEDULLARY CARCINOMA ; P63 EXPRESSION ; GLAND ; CASTLE ; TUMORS ; HISTOGENESIS ; DIAGNOSIS ; ORIGIN
英文摘要

Carcinoma of possible thymic epithelial origin may occur within the thyroid gland, which was first reported by Miyauchi et al. as intrathyroid epithelial thymoma (ITET). ITET is a rare tumor comprising about 0.08% of all primary thyroid malignancies. It is a low-grade thyroid carcinoma with squamous cell differentiation whose overall survival rate was found to be 71%. Lymph node metastasis at surgery was found in 40% and hematogenous metastases developed in bones, liver and lungs. This tumor grows within the thyroid gland and invades into the thyroid parenchyma as well as into the extrathyroid structures. It is a well-circumscribed solid tumor with a sharp tumor border, but is not capsulated. After fixation, the cut surface of the tumor is gray-white in color and is a solid tumor with lobulation. Tumor calcification was not detected in our 15 cases. The tumor cells show solid sheets of growth with occasional keratinization without follicular or papillary structures. Lymphocytic infiltration in the stroma is one of the most characteristic features of this tumor. The tumor cells are polygonal epithelial cells with distinct nucleoli and ill-defined cell border. Positive immunoreactivity for CD5 is a key feature to differentiate it from undifferentiated carcinoma, poorly differentiated carcinoma, medullary (C cell) carcinoma and high-grade squamous cell carcinoma (so-called primary squamous cell carcinoma) of the thyroid. Negative immunoreactivity for calcitonin, TTF1 and thyroglobulin, and positive immunoreactivity for p63 and KIT are also helpful for differential diagnosis. Nuclear atypia is mild and mitoses are less frequent, with an intermediate proliferation index (MIB-1 labeling index is usually less than 20%), which are also helpful to differentiate it from high-grade primary squamous cell carcinoma of the thyroid. The tumors in our 15 cases demonstrate 3 histological subtypes: keratinizing squamous cell carcinoma type, non-keratinizing basaloid cell carcinoma (lymphoepithelioma-like) type and neuroendocrine carcinoma type, which correspond to subtypes of the mediastinal thymic carcinomas.

语种英语
WOS记录号WOS:000317749100001
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55522
专题北京大学临床肿瘤学院_病理科
作者单位1.Kuma Hosp, Dept Surg, Kobe, Hyogo, Japan
2.Kobe Tokiwa Univ, Dept Med Technol, Kobe, Hyogo 6530838, Japan
3.Wakayama Med Univ, Dept Human Pathol, Wakayama, Japan
4.Niigata Canc Ctr Hosp, Div Pathol, Niigata, Japan
5.Peking Univ, Canc Hosp & Inst, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
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Kakudo, Kennichi,Bai, Yanhua,Ozaki, Takashi,et al. Intrathyroid epithelial thymoma (ITET) and carcinoma showing thymus-like differentiation (CASTLE). CD5-positive neoplasms mimicking squamous cell carcinoma of the thyroid[J]. HISTOLOGY AND HISTOPATHOLOGY,2013,28(5):543-556.
APA Kakudo, Kennichi,Bai, Yanhua,Ozaki, Takashi,Homma, Kei-ichi,Ito, Yasuhiro,&Miyauchi, Akira.(2013).Intrathyroid epithelial thymoma (ITET) and carcinoma showing thymus-like differentiation (CASTLE). CD5-positive neoplasms mimicking squamous cell carcinoma of the thyroid.HISTOLOGY AND HISTOPATHOLOGY,28(5),543-556.
MLA Kakudo, Kennichi,et al."Intrathyroid epithelial thymoma (ITET) and carcinoma showing thymus-like differentiation (CASTLE). CD5-positive neoplasms mimicking squamous cell carcinoma of the thyroid".HISTOLOGY AND HISTOPATHOLOGY 28.5(2013):543-556.
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