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学科主题: 公共卫生
题名:
The responses of serum transferrin receptors to iron supplements in subjects with iron-deficiency erythropoiesis and iron-deficiency anaemia
作者: Lin, Xiao-Ming; Tian, Wei; Ma, Le; Long, Zhu; Zhang, Juan; Shen, Xiao-Yi; Zhang, Xiao-Peng
关键词: iron supplementation ; serum transferrin receptors ; reproductive-age women ; serum ferritin
刊名: BRITISH JOURNAL OF NUTRITION
发表日期: 2008-02-01
DOI: 10.1017/S0007114507797040
卷: 99, 期:2, 页:416-420
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: DIAGNOSIS ; THERAPY ; KNEE
英文摘要:

We aimed to study the response of serum transferrin receptors (sTfR) to Fe supplementation in women of childbearing age with Fe-deficiency erythropoiesis (ME) and Fe-deficiency anaemia (IDA). Primary screening was performed in 942 women ranging in age from 18 to 45 years. After Fe-related biochemical indices such as serum ferritin, Zn protoporphyrin and Hb were determined, the subjects were divided into four groups: normal. Fe store depletion, IDE and IDA. A total of 131 women were randomly selected from the normal, IDE and IDA groups. Subsequently. seventy-six women with IDE and IDA were given various doses of Fe (14 mg/d for IDE; 28 mg/d for IDA) with ferrous L-threonate capsules for twelve consecutive weeks. After receiving Fe supplements, the levels of Fe and sTfR were determined at weeks 0. 3 6, 9 and 12. The levels of sTfR in women of childbearing age with IDE and IDA were significantly higher than those in the normal group. After receiving Fe supplements. the levels of sTfR were significantly decreased in women of childbearing age with IDE and IDA, while the levels of serum ferritin were significantly increased. In conclusion, STfR can be used as a reliable indicator for assessing the efficacy of Fe Supplements.

语种: 英语
WOS记录号: WOS:000253045600027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55523
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100083, Peoples R China

Recommended Citation:
Lin, Xiao-Ming,Tian, Wei,Ma, Le,et al. The responses of serum transferrin receptors to iron supplements in subjects with iron-deficiency erythropoiesis and iron-deficiency anaemia[J]. BRITISH JOURNAL OF NUTRITION,2008,99(2):416-420.
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