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Plant sterol-enriched milk tea decreases blood cholesterol concentrations in Chinese adults: a randomised controlled trial
Li, Nicole Y.; Li, Keji; Qi, Zhi; Demonty, Isabelle; Gordon, Michelle; Francis, Lesley; Molhuizen, Henri O. F.; Neal, Bruce C.
关键词Plant Sterols China Randornised Controlled Trials Cholesterol
刊名BRITISH JOURNAL OF NUTRITION
2007-11-01
DOI10.1017/S0007114507754302
98期:5页:978-983
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]DENSITY-LIPOPROTEIN CHOLESTEROL ; CORONARY-HEART-DISEASE ; HYPERCHOLESTEROLEMIC SUBJECTS ; SERUM-CHOLESTEROL ; ESTER MARGARINE ; DIET ; EFFICACY ; STROKE ; PART ; MEN
英文摘要

The cholesterol-lowering effects of plant sterols in a format suitable for use in China have not previously been investigated. We conducted the study to quantify in adult Chinese the effects on blood lipid concentrations of a plant sterol-enriched milk tea powder. The study was a double-blind, randomised trial in which 309 participants were randomised to receive daily 2.3 or 1.5 g plant sterol supplementation or placebo for 5 weeks. The milk tea was consumed with the two fattiest meals of the day with half the assigned daily dose taken on each occasion. Fasting venous blood samples were collected before commencement and upon completion of randomised treatment. The mean age of study participants was 44 years, 62 % were female and 62 % had a history of hypercholesterolaemia. Baseline mean total cholesterol was 5.5 mmol/l and LDL-cholesterol was 3.2 mmol/l. Compared with placebo, the 2.3 g/d plant sterol dose reduced total cholesterol by 0.25 (95 % Cl 0.07, 0.43) mmol/l (P=0.01) and the 1.5 g/d dose by 0.23 (95 % Cl 0.06, 0.41) mmol/l (P=0.01). For LDL-cholesterol the corresponding reductions were 0.17 (95 % Cl 0.00, 0.35) mmolA (P= 0.06) and 0.15 (95 % Cl - 0.02, 0.32) mmol/l (P= 0.08). For neither outcome was there evidence of differences between the effects of the two doses (both P values >0.4). In conclusion, the consumption of plant sterol-enriched milk tea decreased cholesterol concentrations although to a lesser extent than was anticipated. The reason for reduced efficacy is unclear but may be attributable to the novel food format used or the Chinese population studied.

语种英语
WOS记录号WOS:000250752300015
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55528
专题北京大学公共卫生学院
作者单位1.Univ Sydney, George Inst Int Hlth, Sydney, NSW 2050, Australia
2.Unilever Food & Hlth Res Inst, Rotterdam, Netherlands
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing, Peoples R China
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GB/T 7714
Li, Nicole Y.,Li, Keji,Qi, Zhi,et al. Plant sterol-enriched milk tea decreases blood cholesterol concentrations in Chinese adults: a randomised controlled trial[J]. BRITISH JOURNAL OF NUTRITION,2007,98(5):978-983.
APA Li, Nicole Y..,Li, Keji.,Qi, Zhi.,Demonty, Isabelle.,Gordon, Michelle.,...&Neal, Bruce C..(2007).Plant sterol-enriched milk tea decreases blood cholesterol concentrations in Chinese adults: a randomised controlled trial.BRITISH JOURNAL OF NUTRITION,98(5),978-983.
MLA Li, Nicole Y.,et al."Plant sterol-enriched milk tea decreases blood cholesterol concentrations in Chinese adults: a randomised controlled trial".BRITISH JOURNAL OF NUTRITION 98.5(2007):978-983.
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