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学科主题: 公共卫生
题名:
Plant sterol-enriched milk tea decreases blood cholesterol concentrations in Chinese adults: a randomised controlled trial
作者: Li, Nicole Y.; Li, Keji; Qi, Zhi; Demonty, Isabelle; Gordon, Michelle; Francis, Lesley; Molhuizen, Henri O. F.; Neal, Bruce C.
关键词: plant sterols ; China ; randornised controlled trials ; cholesterol
刊名: BRITISH JOURNAL OF NUTRITION
发表日期: 2007-11-01
DOI: 10.1017/S0007114507754302
卷: 98, 期:5, 页:978-983
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: DENSITY-LIPOPROTEIN CHOLESTEROL ; CORONARY-HEART-DISEASE ; HYPERCHOLESTEROLEMIC SUBJECTS ; SERUM-CHOLESTEROL ; ESTER MARGARINE ; DIET ; EFFICACY ; STROKE ; PART ; MEN
英文摘要:

The cholesterol-lowering effects of plant sterols in a format suitable for use in China have not previously been investigated. We conducted the study to quantify in adult Chinese the effects on blood lipid concentrations of a plant sterol-enriched milk tea powder. The study was a double-blind, randomised trial in which 309 participants were randomised to receive daily 2.3 or 1.5 g plant sterol supplementation or placebo for 5 weeks. The milk tea was consumed with the two fattiest meals of the day with half the assigned daily dose taken on each occasion. Fasting venous blood samples were collected before commencement and upon completion of randomised treatment. The mean age of study participants was 44 years, 62 % were female and 62 % had a history of hypercholesterolaemia. Baseline mean total cholesterol was 5.5 mmol/l and LDL-cholesterol was 3.2 mmol/l. Compared with placebo, the 2.3 g/d plant sterol dose reduced total cholesterol by 0.25 (95 % Cl 0.07, 0.43) mmol/l (P=0.01) and the 1.5 g/d dose by 0.23 (95 % Cl 0.06, 0.41) mmol/l (P=0.01). For LDL-cholesterol the corresponding reductions were 0.17 (95 % Cl 0.00, 0.35) mmolA (P= 0.06) and 0.15 (95 % Cl - 0.02, 0.32) mmol/l (P= 0.08). For neither outcome was there evidence of differences between the effects of the two doses (both P values >0.4). In conclusion, the consumption of plant sterol-enriched milk tea decreased cholesterol concentrations although to a lesser extent than was anticipated. The reason for reduced efficacy is unclear but may be attributable to the novel food format used or the Chinese population studied.

语种: 英语
WOS记录号: WOS:000250752300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55528
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Univ Sydney, George Inst Int Hlth, Sydney, NSW 2050, Australia
2.Unilever Food & Hlth Res Inst, Rotterdam, Netherlands
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing, Peoples R China

Recommended Citation:
Li, Nicole Y.,Li, Keji,Qi, Zhi,et al. Plant sterol-enriched milk tea decreases blood cholesterol concentrations in Chinese adults: a randomised controlled trial[J]. BRITISH JOURNAL OF NUTRITION,2007,98(5):978-983.
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